International Journal of Medical and Biomedical Studies <p>&nbsp;</p> <p style="text-align: justify;">&nbsp;</p> <p style="text-align: justify;"><span style="text-align: justify; font-size: 14px;"><strong><span style="font-family: 'lucida sans unicode', 'lucida grande', sans-serif;">International Journal of Medical and Biomedical Studies</span></strong></span><span style="text-align: justify; font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif;"><strong>&nbsp;(IJMBS)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Medical and Biomedical Studies.</span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical Studies||&nbsp; Biomedical Studies ||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences,&nbsp;Pharmacokinetics,&nbsp;Molecular Drug Design, Phytochemistry, Toxicology, Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of&nbsp;Medical and Biomedical Studies.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <hr> <p style="text-align: justify;"><strong style="font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif; text-align: justify;">Top Reasons for publication with us</strong></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong style="font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif;">Other features:</strong> DIDS and DOI: Assigned and Implemented the Open Review System (ORS).</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to <strong><span style="color: #008000;"></span></strong></span></span></p> <hr> <p>&nbsp;</p> IJMBS JOURNAL PUBLISHER en-US International Journal of Medical and Biomedical Studies 2589-868X <p>&nbsp;</p> <p class="caption" style="text-align: center;"><a href="" rel="license"><img style="border-width: 0;" src="" alt="Creative Commons License" width="60" height="21" border="0"></a>International Journal of Medical and Biomedical Studies&nbsp;(IJMBS)<span style="line-height: 1.3em;">&nbsp;</span><span style="line-height: 1.3em;">by </span><span style="line-height: 1.3em;">Articles</span><span style="line-height: 1.3em;"> is licensed under a </span><a style="line-height: 1.3em;" title="Journal of Biomedical and Pharmaceutical Research" href="" target="_blank" rel="license noopener">Creative Commons Attribution 4.0 International License</a><span style="line-height: 1.3em;">.</span></p> Local Drug Delivery in Periodontics- A review <p>Periodontal disease is a multifactorial disease that affects the supporting tissues resulting in the destruction of supporting structure. Non-surgical periodontal treatment has been a cornerstone in the management of periodontitis. However the use of adjuncts along with mechanical debridement have shown better results in the clinical outcome in the management of periodontal disease. Local drug delivery system is the application of antimicrobial or anti-infective agent that would target pathogenic microorganisms by delivering it at the base of the pocket yielding a stable and good clinical outcome along with mechanical debridement. This review aims to focus upon the various local drug delivery systems in the management of periodontitis and its future trends</p> Aparna Venkatasubramanyam Devika Chakravarty ##submission.copyrightStatement## 2018-11-15 2018-11-15 10.32553/ijmbs.v2i6.46 Etiology & Management of Long QT Syndrome <p>Long QT Syndrome (LQTS) is a congenital or acquired condition of the heart rhythm which is characterized on an electrocardiogram by a long QT interval and a type of ventricular tachycardia known as Torsades de Pointes (TdP). The pathophysiology of LQTS may be based in either increases in sympathetic activity in the electrical conduction system, or in abnormal ion flow within the heart, which lead to increases in action potential duration and subsequently prolongs the QT interval, causing predisposition to TdP. LQTS can result from inherited genetic mutations but can also be acquired due to medications such as Class I and Class III antiarrhythmics. Treatment for the condition includes beta-blocker medications, sympathetic denervation procedures, and cardioverter-defibrillator implants. LQTS is of particular interest due to its ability to lead to TdP, which can lead to unconsciousness or sudden cardiac death, and because of its typical onset and severity without other clinical signs which often leads to misdiagnosis. Work must be continued to investigate the drugs which can cause the acquired form of this disease, the genetics of the disease, and the best treatment for varying severities of the disease in order to improve patient outcomes.</p> Sai Palati Rebecca Monastero Elizabeth Varghese Sahana Pentyala Vamiq Mustahsan Sardar Khan Srinivas Pentyala ##submission.copyrightStatement## 2018-11-15 2018-11-15 10.32553/ijmbs.v2i6.42 Soil Erosion as a Function of Natural and Anthropogenic Factors and Its Environmental Consequences <p>The article examines the issues of the possibility of studying erosion and its control. The study proved that the development of soil erosion is based on the forming impact of natural and anthropogenic factors. The degree of potential danger and the possibility of prevention, taking into account the preservation of the environmental situation in the foothills of the Upper Shirvan in the example of the Shamakhi district of the Republic of Azerbaijan, were studied. The main tasks of the study were the determination of the amount and the degree of development of eroded and erosion-prone soils of the foothill zones, carried out on the basis of soil</p> B.H. Aliyev Prof.RAE. Z.H. Aliyev ##submission.copyrightStatement## 2018-11-19 2018-11-19 Impact of Erosion Process to Fertility Ofmountain-Chernozem Situating In South-East Slope of Great Caucasian <p>The complexity, sharp change in the relief condition, the tension of the anthropogenic factors in the Shamakhi region, where we have investigated, has intensified the erosion process. Because of the lack of agrotechnical measures on the slopes, the erosion process has been intensified, the soil is flooded with soil, the physical and chemical properties of the soil have deteriorated, the nutritional elements have declined, the vegetation has been degraded and reached the limit of destruction. For some reason, the object of research was Shamakhi two land cuts were set up to determine the degree of actual erosion of the soil in the village of Melam. which will result in preventive measures to prevent erosion intensities and to develop and implement appropriate preventive measures.</p> Soltanzade Gasim Ali oglu ##submission.copyrightStatement## 2018-11-19 2018-11-19 RESEARCH DESIGN GROUP ACTIVITY TO ENHANCE LEARNING <p><strong>BACKGROUND: </strong>Study designs in research are a difficult topic to understand for undergraduates in MD program unless it is accompanied by some hands on activity with real journal articles published in renowned journals.The objective of the study was to make the understanding the concepts of study designs better and to boost the learning through group activity.</p> <p><strong>METHODS: </strong>A formative activity was conducted in the class after taking the course lectures series on research study designs for the students. A questionnaire was given by the course director to the students after the conduct of a formative activity in the class. The questionnaire was semi structured with mostly close ended questions and few open ended questions. Percentage responses were noted for each category of response and median score was calculated for all responses.</p> <p><strong>RESULTS: </strong>Almost all students (94.8%) were highly satisfied that the activity. 69.8% felt that it was also easy to identify the participants and the study setting in the given article. 65.5% agreed that it was easy for them to identify the prospective or retrospective nature of the study design. Most of the students (81%) felt that group members help in understanding the concepts. After doing the activity, 68.1% students were confident that they could read any journal article.</p> <p><strong>CONCLUSION: </strong>Group activity helped the students to understand and compare the concepts of different study designs in a better way. It made them more confident at the end of the activity with the aid of real journal articles.</p> <p><strong>KEY WORDS: </strong>Research design, group activity, undergraduate students, questionnaire</p> Dr. Sanam Anwar ##submission.copyrightStatement## 2018-12-11 2018-12-11 10.32553/ijmbs.v2i6.65 Scientific Rationale for the Development of Low-Intensity Irrigation Systems in Azerbaijan <p>The results of the study revealed that the mismatch intensity rain rate of water absorption into the soil formation of a surface relief and soil erosion, uneven and shallow soaking imperfection open irrigation system at a superficial irrigation, the need for different irrigation methods in the growing and not growing periods, low coefficient land utilization, high cost of irrigation and other features are, to a certain extent in conflict with the requirements of watering cultivated with techniques for / of crops in an area at the deep groundwater.</p> Qasım Ali oqlu Soltanzade ##submission.copyrightStatement## 2018-11-19 2018-11-19 “EFFECT OF ASPERGILLUS SPECIES ON SKIN INFECTION” <p>We present such a case, manifested by ulceration on skin due to <em>A. niger, </em>which remained undiagnosed for a prolonged period. Although the patient had associated severe fungal infection. Recurrence of the lesion occurred despite repeated anti-fungal therapies. Anti fungal testing was done based on the broth dilution (M-38A, AIIMS, INDIA) method. The culture isolate was found to be sensitive to fluconazole and amphotericin B. Continuation of antifungal therapy improved the symptoms, reducing the size of the lesion.</p> <p><strong>Key words: </strong><em>Aspergillus niger, </em>Skin infection, ulcer<em>, Aspergillus lentulus., Broth</em> dilution.</p> Shivi Saxena Sonia Kukreti ##submission.copyrightStatement## 2018-11-13 2018-11-13 10.32553/ijmbs.v2i6.62 THE ROLE OF MAIT CELL IN PROTECTION AGAINST INFECTION IN-VIVO <p>MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections <em>in vivo</em>. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells accumulated and were activated early in infection, with upregulation of CD25, CD69 and Granzyme B, peaking at 5 days post infection. Activation was modulated via cytokines independently of MR1. MAIT cell-deficient MR1-/- mice showed enhanced weight loss and mortality to severe (H1N1) influenza. This was ameliorated by prior adoptive transfer of pulmonary MAIT cells in both immunocompetent and immunodeficient RAG2-/-gC-/- mice. Thus, MAIT cells contribute to protection during respiratory viral infections, and constitute a potential target for therapeutic manipulation.</p> <p><strong>Key words: </strong>Mucosal associated invariant T cell, T cell, infection, influenza virus.</p> Rupal Sengar ##submission.copyrightStatement## 2018-11-30 2018-11-30 10.32553/ijmbs.v2i6.63 “PROTEIN METABOLISM DEFICIENCY” <p>Metabolism is a complex process that involves a series of chemical reactions in the human body. Alterations in these metabolic processes constitute the disturbances of metabolism causing metabolic disorders. When studying the pathological mechanisms of protein deficiencies it is necessary not only to take into account the composition of the diet. This research discusses the oral aspects of metabolic diseases.</p> <p><strong>Key Words:</strong> Metabolism diseases, protein deficiency syndromes, IEMS, MSUD.</p> Sonia Kukreti Shivi Saxena ##submission.copyrightStatement## 2018-12-04 2018-12-04 10.32553/ijmbs.v2i6.64 CLINICAL PRACTICE GUIDELINES: A STRATEGY FOR EVALUATING PERCEPTION AND QUALITY <p>Clinical practice guidelines (CPG) are recommendations based on a systematic review of scientific evidence and generally these documents are under constant assess. For this matter, a group of health-professionals which belong to Fundación Centro Colombiano de Hipoterapia evaluated the use and quality of the used CPG using AGREE II instrument. The obtained results evidence correlation between both parameters since health-professionals trust in their acquired experience without detracting from the benefits that can be obtained with the use of guidelines. Among the mentioned benefits, improving the quality of care, effectiveness in clinical decisions, and the optimization of costs related to health care can be mentioned. Nonetheless, health-professionals reflect uncertainty in the recommendations generated by the guidelines because of the barriers presented such as strictness in its elaboration, it lacks in updates, audits and evaluations.</p> <p><strong>Key words:&nbsp;</strong>Clinical practice guidelines, assessment, quality.</p> Zendy-Estefany Carmargo-Cardona Andres Bernal-Ballen Jose-Leonardo Cely-Andrade ##submission.copyrightStatement## 2018-12-11 2018-12-11 10.32553/ijmbs.v2i6.66