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font-size: 14px;"><strong><span style="font-family: 'lucida sans unicode', 'lucida grande', sans-serif;">International Journal of Medical and Biomedical Studies</span></strong></span><span style="text-align: justify; font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif;"><strong>&nbsp;(IJMBS)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Medical and Biomedical Studies.</span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical Studies||&nbsp; Biomedical Studies ||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Anesthesia,<strong>&nbsp;</strong>Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences,&nbsp;Pharmacokinetics,&nbsp;Molecular Drug Design, Phytochemistry, Toxicology, Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of&nbsp;Medical and Biomedical Studies.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <hr> <p style="text-align: justify;"><strong style="font-size: 14px; 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In India the burden and prevalence of dengue viral infection is increasing as trends reported globally. Hence, along with global pandemic concern dengue has become major public health concern in India. Dengue is an emerging epidemic disease and several outbreaks among every state of India is being reported from time to time.</p> <p><strong>Material &amp; Methods</strong>: The present cross-sectional study includes 50 Patients who had dengue IgM antibody positive were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant.</p> <p><strong>Results:</strong> &nbsp;10 (20%) patients had normal serum ALT levels, 13 (26%) patients had serum ALT levels raised less than Two-folds, 12 (24%) patients had serum ALT levels raised more than Two-folds, 11 (22%) patients had serum ALT levels raised more than four-folds and 04 (8%) patients had serum ALT levels raised more than ten folds. Among the total study participants 7 (14%) had normal serum AST levels, 14 (28%) patients had serum AST levels raised less than Two-folds, 14 (28%) patients had serum AST levels raised more than Two-folds, 12 (24%) patients had serum AST levels raised more than four-folds and 03 (6%) patients had serum AST levels raised more than ten folds.</p> <p><strong>Conclusion:</strong> Liver function deterioration in dengue fever was varied from normal range of biochemical markers to raised liver function markers. AST elevation was more statistically significant than ALT. Hyperbilirubinemia and raised alkaline phosphatase levels were reported. Low serum albumin levels were associated with critical phase of the liver disease.</p> <p><strong>Key words:</strong> Dengue fever, Hyperbilirubinemia, AST, ALT.</p> Dr. Radhey Shyam Gupta ##submission.copyrightStatement## Sun, 04 Aug 2019 11:49:39 -0400 ASSESSMENT OF CLINICAL PROFILE OF PATIENTS WITH ALCOHOLIC LIVER DISEASE <p><strong>Background:</strong> Alcohol consumption affects both mental and physical function of the body and hence called as “dual disease” because it has mentioned in etiology of morbidity in both the components of the body. According to the reports of World Health Organization there were more than 150 million people worldwide has indulged with alcoholism.</p> <p><strong>Material &amp; Methods</strong>: The present prospective study was conducted at department of general medicine of our tertiary care hospital. 100 Patients who were diagnosed as acute onset alcoholic liver disease were enrolled from outdoor and from ward by simple random sampling.</p> <p><strong>Results: </strong>The most common clinical feature recorded among study participants was of nausea and vomiting seen in 46 (92%) of patients, which was followed by jaundice reported among 43 (86%) of patients. Hepatomegaly was reported among 37 (74%) of patients, which was followed by signs of liver failure reported among 30 (60%) patients, followed by anorexia reported among 29 (58%) of patients. Splenomegaly was reported among 17 (34%) of patients, fever was reported among 13 (26%) of patients, abdominal pain was reported among 12 (24%) of cases and ascites was reported among 8 (16%) study participants.</p> <p><strong>Conclusion:</strong> &nbsp;We concluded from the present study that larger quantities of alcohol consumption for a longer duration of time result in high morbidity and mortalities. Alcoholic liver disease is not only a medical burden but also a social burden which leads to frequent hospitalization and unwanted out of pocket expenditure.</p> <p><strong>Key words:</strong> alcoholic liver disease, liver cirrhosis, hepatomegaly.</p> Dr. Chetan Nayak ##submission.copyrightStatement## Sun, 04 Aug 2019 12:07:31 -0400 A CLINICAL PROFILE OF PERFORATED DUODENAL ULCER <p>Background: Duodenal ulcer is a common condition characterized by the presence of a well- demarcated break in the mucosa that may extend into the muscularis propria of the duodenum.</p> <p>Methods: This prospective observational study was conducted in the Department of Surgery, Dr. Rajendra Prasad Government Medical College Kangra at Tanda, consisting of patients hospitalised&nbsp;&nbsp; in department of surgery. Patient data was collected from all patients showing clinical signs and symptoms of perforated duodenal ulcer, attending Dr. RPGMC TANDA during 1 year period after ethical clearance of study.</p> <p>Results: The mean age of patients was 43 years with maximum number of patients were of age group between 19-45 years. Ninety two percent of patients were male and 8% were female. Sixty two percent of patients with duodenal ulcer perforation belong to low socioecnomic strata. Ten percent of patients&nbsp; presented within 24 hours after onset of symptoms. Ten percent of patients out of 90 % which presented after 24 hours were in shock.</p> <p>Conclusion: Perforation of duodenal ulcer remains a frequent clinical problem in our environment predominantly affecting 19-45 years group labourer males known to suffer from duodenal ulcer.</p> <p><strong>Keywords:</strong> Duodenal Ulcer, Perforation, Clinical Profile</p> Dr. Vishal Kaundal, Dr. Vikrant Sharma ##submission.copyrightStatement## Mon, 05 Aug 2019 10:01:42 -0400 MARITAL ADJUSTMENT AMONGST SPOUSE AND PATIENT WITH BIPOLAR DISORDER <p>Background: Bipolar disorder (BD) is a complex mental disorder which is characterized by episodes of depression/ mania/hypomania/mixed states along with interepisodic phases of remission.&nbsp; This study is conducted with hope that a better understanding of marital functioning will help to address the needs of both patient and spouse resultantly improving the outcome of marriage and illness.</p> <p>Methods: This study is conducted with 60 married patients with BD along with their spouses and 61 subjects free of any psychiatric disorder. Spouses and controls were age and gender matched.&nbsp;</p> <p>Results: Less than half of the spouses felt cheated and about one-third of the spouses reported that they felt (to little or some extent) that they should separate from their spouses. About one-fifth (21.7%) of the spouses believed that marriage can be a treatment of mental illnesses and about one-fourth (23.3%) believed that marriage can be a cure from mental illnesses. About one-third (36.7%), of the spouses felt that marriage can help in improving the mental illness. About half of the spouses (45%) also believed that marriage can worsen mental illness.</p> <p>Conclusion: We conclude that when comparisons were made based on the onset of illness prior or after marriage, it was seen that higher proportion of spouse of patients with bipolar disorder who had illness prior to marriage were worried that children may develop mental illness and were not fully satisfied with the child care provided by mentally ill spouse.</p> <p><strong>Keywords:</strong> Bipolar disorder (BD), Marriage</p> Dr. Anita Thakur ##submission.copyrightStatement## Mon, 05 Aug 2019 12:12:56 -0400 HISTOPATHOLOGICAL AND IMMUNOFLUORESCENT STUDIES IN CERTAIN SKIN DISORDERS <p>Background: This study was an attempt to evaluate the role of direct immunofluorescent technique to demonstrate the immunoglobulins in certain skin disorders, which are likely to have immunological mechanism in their pathogenesis.</p> <p>Methods: This study was carried out in department of Pathology, Sardar Patel Medical College &amp; Associated group of Hospitals, Bikaner. This study was hospital based study on skin biopsy specimen recieved in the department of Pathology during the study period.</p> <p>Results: On immunofluorescent studies of these skin biopsies, 12 out of 16 cases of pemphigus were positive for fluorescence was intracellular area in epidermis. In lichen planus&nbsp; 5 out of 7 cases were positive for fluorescence and commonest site was dermo-epideremal junction. In dermatis-herpatiformis 2 out of 3cases were positive for fluorescence and commonest site was dermo-epideremal junction. IgG was commonest type of immunoglobulin’s demonstrate in 12 out of 16 cases of pemphigus followed by IgM (5 cases), IgA(1cases). In lichen planus&nbsp; IgM was commonest type of immunoglobulin’s demonstrate in 5 out of 7 cases of pemphigus followed by IgG (3 cases), IgA(1cases). In dermatitis herpatiformis IgA was commonest type of immunoglobulin’s demonstrate in 2 out of 3 cases of pemphigus followed by IgM (1 cases).</p> <p>Conclusion: We conclude that the demonstration of immunoglobulins in skin biopsies by direct fluorescent technique is a quite useful adjunct in diagnostic confirmation of pemphigus, lichen planus and dermatitis herpetiformis.</p> <p><strong>Keywords</strong>: Direct immunofluorescence, Pemphigus, Histopathology.</p> Rekha S, Vineet Kumar, Vanita Kumar, R D Mehta ##submission.copyrightStatement## Wed, 07 Aug 2019 11:26:01 -0400 A PROSPECTIVE RANDOMIZED STUDY COMPARING CARBOPLATIN AND CAPECITABINE BASED CHEMORADIATION VERSUS CARBOPLATIN AND 5FU BASED CHEMORADIATION IN LOCALLY ADVANCED HEAD AND NECK CANCER <p>Background: In this study we took care of convenience for the patient and hospital staff while limiting hospital burden at the same time and compare its toxicities and disease response with concurrent Carboplatin with 5FU based CRT.</p> <p>Methods: This prospective randomized study was conducted in the Department of Radiotherapy &amp; Oncology, Regional Cancer Centre , IGMC, Shimla. It included all the previously untreated adult patients of squamous cell carcinoma of Head and Neck with histologically confirmed diagnosis and no evidence of distant metastasis.</p> <p>Results: Treatment was interrupted in 16.2% of patients in the Carboplatin with Capecitabine arm and 8.1% patients in the Carboplatin with 5FU arm.</p> <p>Conclusion: Higher toxicities were seen in carboplatin with Capecitabine arm as compared Carboplatin with 5FU arm though not statistically significant. This again require further validation on large sample size.</p> <p><strong>Keywords:</strong> Carboplatin, Capecitabine, 5FU, Cancer.</p> Shalini Verma ##submission.copyrightStatement## Wed, 07 Aug 2019 11:50:57 -0400 TO ANALYSE THE DEFERRAL INCIDENCE AND ITS PATTERN AMONG THE BLOOD DONORS IN A TERTIARY CARE CENTRE IN NORTH INDIA. <p>Background: Blood donor programme is vital to any transfusion service. This process of blood donation involves voluntary and non remunerated blood donors. The objective of donor screening is to minimize the chances of transmitting infectious agents to recipients.</p> <p>Material and Method: The study was conducted during one year duration from 2017-2018. A total of 700 donors are deferred against 9556 blood donors recruited on the basis of clinical history and brief medical examination in blood bank and voluntary blood donation camps. Donors were deferred temporarily or permanently.</p> <p>Result: Out of 700 deferred donors; 546 were voluntary and 154 were replacement blood donors. Male (601) outnumbered female (99). There were 682 temporary and 18 permanent deferral. Most common age group for deferral was 17-30 yrs (490). Common causes included anemia(142), on medication(108), underweight(83) and high blood pressure(72).</p> <p>Conclusion: Donor selection process is a most important preliminary step in blood banking and should follow stringent medical and regulatory rules. Studying and analysing the profile of blood donors will help to identify sections of the population which could be targeted to increase the pool of voluntary blood donors. Every attempt should be made to decrease the donor deferral keeping in view the safety of both donor and recipients.</p> <p><strong>Keywords:</strong> Blood donor, Deferral, Voluntary, Temporary, Permanent.</p> Dr. Surbhi Jain ##submission.copyrightStatement## Wed, 07 Aug 2019 12:17:31 -0400 COMPARISON OF BUPIVACAINE AND BUPIVACAINE WITH FENTANYL IN LOWER LIMB ORTHOPAEDIC SURGERIES <p><strong><em>INTRODUCTION</em></strong><em>: A</em><em> commonly used technique for lower limb surgeries is subarachnoid blockade. If there is inadequate control of pain, will affect quality, and functional recovery, also there is chance of postsurgical complications, and the risk of persistent postsurgical pain. Use of epidural analgesic technique for lower limb surgeries should provide better pain relief with minimal side effects, leading to improved outcome. Bupivacaine hydrochloride is a local anaesthetic drug, which was used clinically in 1963. Bupivacaine acts mainly by blockade of voltage-gated Na+ channels in the axonal membrane and possibly has a further effect on presynaptic inhibition of calcium channels. Fentanyl is a powerful synthetic opioid which is similar to morphine but is 50 - 100 times more potent, which is used to treat patients with severe pain, especially after surgeries. </em></p> <p><strong><em>MATERIAL AND METHODS</em></strong><em>: </em><em>This prospective randomized study was conducted in the </em><em>department of anaesthesiology at </em><em>Rajiv Gandhi Institute of Medical Science, Adilabad,</em><em> to compare single shot epidural 8ml 0.5 % bupivacaine alone verses 8ml 0.5% bupivacaine along with 0.50 mcg Fentanyl. Total of 80 patients with ASA(American society of anaesthesiologists)&nbsp; I and II with age group between 24 to 56 years were included and 40 patients each were randomly placed in bupivacaine alone group (Group 1) and fentanyl in combination with bupivacaine group (Group 2). Written informed consent from all the patients was obtained. </em></p> <p><strong><em>RESULTS:</em></strong> <em>Mean (SD) systolic blood pressure was observed to be 128.45(12.47) and 130.25(11.55) in group 1 and group 2 respectively. Mean time for T 10 sensory block was significantly earlier in group 2 12.03(1.12) compared to group 1 18.24(2.54). Onset of motor block was observed to differ significantly, where onset was significantly earlier in group 2 23.17(1.77) in comparison to group 1 28.45(1.49). </em><em>The first analgesic requirement in Group 1 was earlier at 198.20 + 11.49 min as compared to Group 2 at 279.34 + 18.42 min. </em></p> <p><strong><em>CONCLUSION</em></strong><em>: Bupivacaine with Fentanyl enhances the onset of action and duration of effect for two segment regression. In present study the time to achieve T10 sensory block was early in Group 2 12.03(1.12) compared to group1 18.24(2.54).Onset of group2 23.17(1.77) in comparison to group1 28.45(1.49). Time of first analgesic requirement was found to be earlier at 279.34 + 18.42 minutes in group2 in comparison to group1 198.20 + 11.49 minutes.</em></p> Dr. Suraj Dahale, Dr. Satish Kale ##submission.copyrightStatement## Thu, 08 Aug 2019 05:44:04 -0400 “SURVEY ON THE PREVALENCE OF MOSQUITO BORNE DISEASE IN THE AREAS OF KOTA - RAJASTHAN” <p>The two major varieties are <em>Plasmodium falciparum</em> and <em>Plasmodium vivax.</em> <em>Plasmodium falciparum</em> is the most wide spread and dangerous of the four. Rajasthan also provides favourable environment to mosquitoes. Kota lies on latitude – 25°10` N &amp; longitude – 75°50` with the intervention of Chambal river coming from Madhyapradesh and running throughout Kota city irrigating various rural areas via man made channels. Kota has also been a favourite place for mosquito breeding &amp; hence a record of malaria &amp; dengue cases reported are more from neighbouring Bundi (Roteda) &amp; Kota city in comparison to other districts of Rajasthan. In Kota city maximum cases of malaria occur during August to October. The mosquitoes are more active in humid atmosphere. The rainy season falls between June to September. Rainfall provides water for mosquito breeding as well as increases humidity of the atmosphere for survival of the mosquitoes.</p> <p><strong>Key words:</strong> Mosquito-borne diseases, anopheline, mosquitoes and malaria.</p> Dr. Smriti Johari ##submission.copyrightStatement## Thu, 08 Aug 2019 05:49:55 -0400 A COMPARATIVE STUDY TO EVALUATE THE CONCURRENT CHEMORADIOTHERAPY VERSUS RADIOTHERAPY ALONE IN THE MANAGEMENT OF BREAST CANCER <p>Background: We designed a study to compare radiotherapy alone in sandwich set up with concurrent chemo radiotherapy in the management of breast cancer.</p> <p>Methods: This study was conducted on 30 patients suffering from advanced breast carcinoma who visited Department of Radiotherapy and Clinical Oncology, S. N. Medical College, Agra. All these patients were referred from Department of Surgery, S.N. Medical College or from other nearby centers. Out of 30 patients 25 patients completed the treatment and were enrolled for analysis.</p> <p>Results: 84.61% of patients had no evidence of disease and were alive without disease in arm A vs 100% in arm B. The overall survival at 1 year was 100% in both the arms. The disease free survival at 1 year was 84.61% in arm-A and 100% in arm-B.</p> <p>Conclusion: The overall adverse effects were higher in ARM-B (concurrent arm) as compared to ARM-A but it was acceptable without any drop out during the treatment.</p> <p><strong>Keywords:</strong> Breast cancer, concurrent chemoradiotherapy, neoadjuvant therapy, locally advanced disease.</p> Jyoti Singh ##submission.copyrightStatement## Fri, 09 Aug 2019 10:42:38 -0400 EVALUATION OF FACTORS ASSOCIATED WITH ASYMPTOMATIC AIRFLOW OBSTRUCTION <p><strong>Background:</strong> Obstructive Airway Disease also imposes economic burden and increase the out of pocket expenditure of the patient and the country.(1)&nbsp; In previous researches it was found that obstructive Airway Disease were reported frequently and often present with complications. The most commonly seen obstructive airway diseases are COPD, Asthma, Bronchitis, Bronchiolitis and Bronchiectasis.</p> <p><strong>Material &amp; Methods</strong>: In the present study100 Asymptomatic Patients with not previously diagnosed Obstructive Airway disease and patients with no evidence of any physical disease were included in the study. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant.</p> <p><strong>Results:</strong> Out of the total, 15 (20.3%) of the male population and 3 (11.5%) of the female population had asymptomatic airflow obstruction with statistically significant difference (P value &lt;0.05). Out of the total on the basis of distribution according to BMI (Kg/m2), 7 (15.5%) patients had airflow obstruction among lower BMI population and 11 (20%) patients had airflow obstruction among higher BMI population with statistically non-significant difference (P value &gt;0.05). ). Out of the total on the basis of distribution according to weight, 4 (11.1%) patients had airflow obstruction among age &lt;50 years population and 14 (21.8%) patients had airflow obstruction among age &gt;50 years population with statistically significant difference (P value &lt;0.05).</p> <p><strong>Conclusion:</strong> There was high burden of undiagnosed asymptomatic obstructive airway disease reported among patients who were males, higher age and had higher BMI. Patients who were current smokers had maximum airflow obstruction in compared to patients who never had smoking habit and patients who were ex-smokers.</p> <p><strong>Key words:</strong> Obstructive Airway Disease, COPD, Spirometry.</p> Dr. Deepali Kamdar ##submission.copyrightStatement## Fri, 09 Aug 2019 12:53:02 -0400 A STUDY OF UTILITY OF DRAIN FLUID PH FOR RAPID DETECTION OF INFECTIOUS COMPLICATION AFTER ABDOMINAL SURGERY <p>Background: The onset of infectious complications following abdominal surgery may be insidious, their presence obscure and the diagnosis difficult.</p> <p>Methods: A prospective study of patient in whom emergency laprotomy was performed and post operative abdominal drain fluid analysis was done by ph for rapid detection of infectious complications.</p> <p>Results: In our study those patients who developed intraabdominal complications (Failure) there 65.3% of samples have pH &lt;7.1 and 34% samples have pH &gt;7.1.While in patients who considered cured &amp; improved 76.62% samples have pH &gt;7.1 &amp; 23.37% have pH &lt;7.1</p> <p>Conclusion: The pH during the postoperative follow-up period to evaluate the potential for rapid, simple, and early detection of infectious complications following abdominal surgery.</p> <p><strong>Keywords:</strong> PH, Infection, Drain, Fluid.</p> Dr. Rohit Yadav ##submission.copyrightStatement## Sat, 10 Aug 2019 11:32:56 -0400 ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL. <p><strong>Background: </strong>Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM.</p> <p><strong>Methodology: </strong>The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin.</p> <p><strong>Results: </strong>A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control.</p> <p><strong>Conclusion: </strong>The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control.</p> <p><strong>Keywords: </strong>Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.</p> Shah Namrata Vinubhai, Pardeep Agarwal, Bushra Fiza, Ramkishan Jat ##submission.copyrightStatement## Sun, 11 Aug 2019 08:32:21 -0400 HEMATOLOGICAL MODULATION IN REGULAR PRACTICE OF YOGA <p>Background: A significant effect of yoga has been noticed in decreasing the blood glucose level, the heart rate, and systolic and diastolic blood pressure. Blood contains predominantly three types of blood cells including red blood cells (RBC), white blood cells (WBC) and Platelets.</p> <p>Methods- The study was carried out 100 volunteers. Study group comprised 50 male and 50 female healthy subjects of 18-20 years. Hematological parameters like total RBC Count, total W.B.C Count, hemoglobin content/dl and total Platelet count were determined by Improved Version of automated hematology auto-analyzer. For this Hemogram study, 5 ml of blood was collected in EDTA Vial under aseptic precautions.</p> <p>Results: Regular practice of yoga for 3 months significantly improved the R.B.C., W.B.C., Platelet count and Hb content.</p> <p>Conclusion- We concluded that regular practice of yoga for promotes trafficking of the stem cells from bone marrow and improve hematological parameters in anemia.</p> <p><strong>Keywords:</strong> Yoga, hematological parameters, Regular.</p> Deepak Goyal, Sadhana Agarwal ##submission.copyrightStatement## Sun, 11 Aug 2019 11:05:58 -0400 A HISTOPATHOLOGICAL STUDY ON POST-MORTEM SPECIMENS RECEIVED TO DEPARTMENT OF PATHOLOGY, GOVERNMENT MEDICAL COLLEGE, KADAPA. <p>Histopahtological examination of post-mortem specimens is done to establish the cause of death, due to pathological changes in the tissues. Present study was done to between 2014 - 2015 (5 years study) consisting of 184 cases.</p> <p><strong>Keywords: </strong>Histopathology, Postmortem specimen, Emphysema, Chronic venous congestion of lung</p> Dr G.Sobha Rani, Dr. B.Naga Raja, Dr V.Nagesh Kumar ##submission.copyrightStatement## Mon, 12 Aug 2019 09:20:24 -0400 C REACTIVE PROTEIN IN DIFFENTIAL DIAGNOSIS OF PLEURAL EFFUSION <p>Present study has included 95 Pleural Effusion patients. Pleural fluid were collected from them and classified as Transudate and Exudate according to the standard criteria. Pleural Fluid C-Reactive Protein (CRP) concentrations indicated towards diagnosis and severity of exudates. CRP in pleural fluid is a helpful tool in diagnosis and monitoring of pleural effusion patients.</p> <p><strong>Keywords: </strong>Pleural effusion, Exudate, CRP</p> Kaushik Kar, Satwika Sinha, Anindya Dasgupta ##submission.copyrightStatement## Tue, 13 Aug 2019 00:00:00 -0400 TO STUDY THE MANAGEMENT OF LIVER ABSCESS <p>Background: Liver is an important and vital organ of the body. This organ is subjected to numerous systemic infections viral, bacterial and parasitic and lies at the distal end of the portal circulation; it is therefore bathed with portal blood containing viruses, bacteria parasites, ova, products of digestion and other antigens.</p> <p>Methods: This study was a cross sectional study of patients attending surgery department in J L N Medical College, Ajmer Rajasthan. The study was conducted over a period of 1 year on 100 patients of liver abscess.</p> <p>Results: 3 mortalities were found in amoebic liver abscess patients who had ruptured liver abscess and was undertaken for surgical intervention</p> <p>Conclusion: We suggest early recognition of clinical features and prompt abdominal USG as cost-effective means for treatment initiation and reducing complications.</p> <p><strong>Keywords:</strong> Amoebic liver abscess, Pyogenic liver abscess, Treatment.</p> Dr. Kalpana Agarwal, Dr. Shiv Kumar Bunkar, Dr. Dony Devasia, Dr. Kush Verma ##submission.copyrightStatement## Wed, 14 Aug 2019 13:01:23 -0400 TO ASSESS THE ADVERSE EFFECT PROFILE OF SECOND LINE DRUG IN TB PATIENTS <p><strong>Background: </strong>A retrospective and prospective study including LPA /AFB CULTURE proven cases of MDR TB. Data will be collected from the patient attending the OPD &amp; IPD in the Dept. of Respiratory Medicine Index Medical College, Indore.</p> <p><strong>Result: </strong>Out of 226 patients, 183 patients continue on treatment and 8 patients get cure and 12 patients dead and 12 patients defaulted the treatment.</p> <p>Out of 226 patients, the present study shows that Gastrointestinal side effects are the most common 42.5%. 12 patients have renal toxicity and 8 patients have Arthalgia and 6 patients have cutaneous reactions and 14 patients developed hepatitis and 7 patients have some psychiatric illenss and 7 patients developed hearing defect.</p> <p><strong>Conclusion:</strong> Overall, these findings emphasize the importance of continuing the systematic surveillance of M. tuberculosis isolates to monitor the trends of drug resistance in different patient categories as well as its association with&nbsp; HIV across the country to timely modify and strengthen the national programs in order to prevent the emergence of MDR-TB strains and avert the threat of XDR-TB.</p> <p><strong>Keywords: </strong>Profile, second Line Drug &amp; TB.</p> Dr. Kshitiz Chourasia, Dr. Kumar Girendrae, Dr. Vinod Patel, Dr. Mudra Khare ##submission.copyrightStatement## Wed, 14 Aug 2019 00:00:00 -0400 CLINICAL PROFILE OF PATIENTS WITH VERNAL KERATOCONJUNCTIVITIS <p>Background: Vernal keratoconjunctivitis (VKC) is a chronic, bilateral, recurrent ocular inflammatory condition found in individuals predisposed by their atopic background and associated with secondary keratopathy.</p> <p>Methods: 90 patients with VKC selected at random, who attended the Department of&nbsp; ophthalmology, DRPGMC, Kangra at Tanda were the subjects of this study.</p> <p>Results: Major symptoms seen in this study group are itching, watering and photophobia. Congestion was present in 78 patients of VKC and 12 patients had no congestion at presentation. Perilimbal pigmentation was seen in 70 patients out of 90 studied subjects of vernal keratoconjunctivitis. In this study 40 patients had perilimbal conjunctival hypertrophy and 50 patients did not have conjunctival hypertrophy. 12 patients had clinical sign of Horner Trantas dots in this study indicating severity of vernal keratoconjunctivitis.</p> <p>Conclusion: VKC was common in males, during hot climate. Limbal type of VKC was more commonly present.</p> <p><strong>Keywords:</strong> Eye,Clinical profile, Vernal keratoconjunctivitis</p> Shailender Minhas, Rajeev Tuli, Gaurav Sharma, Vikram Mahajan ##submission.copyrightStatement## Thu, 15 Aug 2019 12:36:47 -0400 FORMULATION AND EVALUATION OF FILM COATED DASATINIB IMMEDIATE RELEASE TABLETS <p>Immediate release tablets defined as solid dosage form which contain a medicinal substance or active ingredient which disintegrates rapidly within minutes after administered through oral route. Dasatinib inhibits the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines over expressing BCR-ABL. Main criterion for immediate release dosage form is poor solubility of the drug and need the immediate action of drug to treat&nbsp; any unwanted defect or disease. Current research work is mainly deals with development of patent non-infringing generic version for sprycel (IR tablets of Disatinib) with direct compression method by using croscarmellose sodium, sodium starch glycolate and crosspovidone as the superdisintegrants with 2.5%, 3.5% and 4.5% concentrations. All the formulations were evaluated for their pre-compression and post-compression parameters. Among all the formulations formulation F3 (4.5 % crosscormellose sodium) was found to be optimized formulation based on its dissolution profile comparison was found to be optimized formulation based on its dissolution profile comparison with innovator product before and after stability studies.</p> <p><strong>Keywords:</strong> Immediate release tablets, crosscarmellose sodium, cross povidone.</p> Poreddy Srikanth Reddy, V. Alagarsamy, P. Subhah Chandra Bose, 3Damineni Sarita, V. Sruthi ##submission.copyrightStatement## Fri, 16 Aug 2019 05:31:09 -0400 PREDICTION OF ACUTE PANCREATITIS OUTCOME USING MODIFIED CT SEVERITY INDEX <p><strong>Aims: </strong>To assess the severity of acute pancreatitis (AP) using computed tomography (CT) modified CT severity index (MCTSI) and to correlate with clinical outcome measures.</p> <p><strong>Materials and methods:</strong> After approval from institutional ethics committee, a prospective study was conducted at the department of Radiodiagnosis, JNIMS, Imphal in collaboration with department of Surgery and Medicine among 30 patients of acute pancreatitis. Consecutive sampling was used. Outcome variables were length of hospital stay, ICU admission, infection, organ failure and mortality. Acute pancreatitis severity was graded using MCTSI which included based on Grade 0, 2, 4, 6, 8 and 10. Test of significance was performed using chi-square test (Yates corrected).</p> <p><strong>Results: </strong>Mean age was 36.3±10.7 years and male predominance was seen in this study. There were 26.7% of mild, 66.7% cases of moderate and 6.7% of severe acute pancreatitis in this study according to MCTSI. Severity scores were associated with increased ICU admission and mortality in this study.</p> <p><strong>Conclusion: </strong>MCTSI is useful in outcome prediction/complications of acute pancreatitis.</p> <p><strong><em>Keywords: </em></strong><em>Acute pancreatitis, MCTSI, necrotizing pancreatitis</em><em>, outcome</em></p> Dr. Khumanthem Shailendra Singh, Dr. Nongthombam Thomson Luwang, Dr. Ngangom Lilavati, Dr. Khumanthem Savana, Dr. Arunoday Kumar ##submission.copyrightStatement## Fri, 16 Aug 2019 09:04:17 -0400 INFLUENCE OF DIFFERENT IMPLANT ABUTMENT CONNECTION DESIGNS ON ABUTMENT SCREW LOOSENING IN DENTAL IMPLANT SYSTEMS – A SYSTEMATIC REVIEW. <p><strong>Background: </strong>Dental implants have provided an alternative method of prosthetic rehabilitation with high long-term success rates. However, mechanical or biological complications may occur with implants amongst which loosening of the screw is very common. Loosening of the screw might cause misfit of implant‒abutment interface and may occur due to preload loss subsequent to inadequate&nbsp; initial torque, distortion of the screw, wear of the screw, overloading, and micro-movements because of functional loading. The implant-abutment connection design like internal hex, external hex and morse taper may affect the screw stability. The effect of various implant-abutment connections on the stability of abutment screw has been discussed in this systematic review.</p> <p><strong>Aim: </strong>The aim of this review is to assess and compare effect of different abutment connections on loosening of the screw.</p> <p><strong>Data Sources:</strong> An online search was made for the articles using Google Scholar and PubMed.</p> <p><strong>Study Eligibility Criteria: A</strong>rticles published in English language or those articles that have a detailed summary in English language were included. Articles published between 1<sup>st</sup> January 2000 and 30<sup>th</sup> September 2018 were selected. Scientific research papers, Randomized controlled trials were included with data on the effect of various implant abutment connections on the loosening of the screw.</p> <p><strong>Results:</strong> Out of 449 articles that were identified through electronic database searching. 19 articles were selected. These articles were screened for duplicates and 7 articles were obtained after eliminating the duplicates. None were excluded after screening of the duplicate articles. This review provides an understanding of effect of various abutment connections on loosening of the screw.</p> <p><strong>Limitations: </strong>Few articles do not give concrete conclusions due to smaller sample sizes, differences inter-study sample population, variety of groups compared<strong>.</strong></p> <p><strong>Conclusions: </strong>Out of all studies that were evaluated few stated that internal hex connection design had least screw loosening compared to external hex and morse taper while the other studies were inconclusive.</p> <p><strong>Keywords: </strong>Dental Implant, Implant-Abutment Connection, Screw Loosening</p> Dr. Prerna N Kulkarni, Dr. Nilesh S Bulbule, Dr. Dilip M Kakade, Dr. Shalu S Mondal, Dr. Akanksha Bhandari ##submission.copyrightStatement## Fri, 16 Aug 2019 00:00:00 -0400 ACUTE CALCULOUS CHOLECYSTITIS IN A YOUNG FEMALE PATIENT: A UNIQUE CASE <p>Acute cholecystitis needs to be rapidly diagnosed and treated correctly. The classic patient characteristics were obese, increasing age, and being female. In a few cases, cholecystitis can occured in an atypical patient, such as in young age. Here, we report a 25-year-old obese female patient that came with right upper abdominal pain which was associated with nausea and vomiting. From imaging studies, we found that she had distended gallbladder with multiple stones. Open cholecystectomy was done and patient did well postoperatively. Acute cholecystitis had to be suspected in all age, especially in patient with another risk factor like obesity in our case.</p> <p><strong>Keywords</strong>: acute cholecystitis, gallstone, cholecystectomy</p> Christina Permata Shalim, Ni Nengah Tuti Arianthi, Made Suma Wirawan ##submission.copyrightStatement## Thu, 08 Aug 2019 05:40:48 -0400 ILEAL PERFORATION DUE TO INGESTED METALLIC COINS <p>A 28-year-old man was admitted in Emergency Department with features of the peritonitis. This patient underwent emergent exploratory laparotomy with a preoperative diagnosis of peptic ulcer perforation based on his history. Two coins were removed from perforated ileum. The patient was discharged on 5<sup>th</sup> POD with an ileostomy following an uneventful hospital stay. Interesting facts reported with this case was absence of any specific history of coins ingestion and no detection of these coins in preoperative abdominal skiagram which was further vitiated by presence of fever and medical history.</p> Dr. Anubhav Arya, Dr. Neel Kamal Gola, Dr. Amit Kumar ##submission.copyrightStatement## Sat, 10 Aug 2019 05:18:46 -0400