A CLINICAL STUDY OF KATAKA CHURNA ON MALE SEXUAL DYSFUNCTION & POOR VISION

Context: Excessive sexual activity or masturbation causes oxidative stress, damaging the inner layer of the eye where the rods and cones are located. Think of rods and cones as molecular strainers that catch light. Oxidative stress of ocular tissues is a major culprit behind vision problems, such as eye floaters, glaucoma and cataracts. Aim: To evaluate the efficacy of Kataka churna in the management of Male sexual dysfunction and Poor vision. Methodology: 50 patients who have Timira (Poor vision) with associated symptoms Male sexual dysfunction (MSD) had selected for randomised control trial based on inclusion & exclusion criteria. Results: The trial drug Kataka churna showed statistically significant results in subjective parameters of poor vision (Timira roga) but insignificant in MSD.


Introduction:
Eyesight is the God's greatest gift to humankind, the blessing that allows us to see our surrounding and feel the exquisite beauty of God's creation.Life without eyesight is miserable and valueless.Hence, it is very important to protect vision at any cost.
Normal vision is being able to see a certain size line on the eye chart [the Snellen chart] from 6 meters away; a normal eye has a near point of 25cm to clear vision.
Acharya Sushruta classified the diseases of eye, according to the site of lesion.One group of eye diseases, known as 'DrishtigataRoga' are responsible for visual impairment, both partial and complete.

Drishti:
The word Drishti has used in two different meanings in Ayurvedic classics.

Timira
comes under the group of DrishtigataRoga.Sushruta considers Timira, Kacha and Linganasha as the progressive clinical stages of the disease Linganasha vi .Many of the clinical features described for Timira are having similarities with the refractive errors.
Aacharya Sushruta described Atimaithun (excessive sexual activity), is an etiological factor causing Netraroga.vii Aacharya Sushruta not described separate etiological factors of Drishtiroga, there for all the etiological factors of Netraroga also causing Dristi-gataroga.
Need of study:-According to study, excessive sexual activity or masturbation causes oxidative stress, damaging the inner layer of the eye where the rods and cones are located.Think of rods and cones as molecular strainers that catch light.When the strainer become damaged due to oxidative stress, or a deficiency in cGMP, nitric oxide or acetylcholine, the rod visual sensory nerves experience a depletion of C3G phytochemicals, which stabilizes visual input.C3G phytochemicals allow the eye to process images, like a graphics card in a computer.When C3G phytochemicals see a reduction, the eye cannot process images fast enough.The blurry, squiggly lines known as eye floaters are the result of reduced C3G chemicals trying to process images.
Men who ejaculate multiple times a day experience deficiencies in these neuro-chemicals necessary for health eyes and sexual function.Per recent studies, a correlation of eye floaters and sexual dysfunctions, e.g., weak erections, premature ejaculations and impotence, were found.Research has further shown that oxidative stress damages the sympathetic nerves and smooth muscles of the iris.Oxidative stress of ocular tissues is a major culprit behind vision problems, such as eye floaters, glaucoma and cataracts.In fact, Western Europe scientist found almost half of individuals with inflammation involving the posterior segment of the eye had visual impairment.The inflammatory response was often triggered by infection, systemic and metabolic disorders, such as sexual exhaustion. [1] [3] [4] [5] [6]viii Patient having sexual dysfunction generally takes sex inducing drugs like sildenafil and tildenafil which cause many side effects include blurred vision and changes in colour vision, abnormal ejaculation, and prolonged erections including abnormal vision, change in colour vision and blurred vision.However, in ayurveda drugs used for the same do not cause side effects like sildenafil and tildenafil.
The enzyme that Viagra-like drugs inhibit is found primarily in two places in the body, the erectile tissue of the penis and the retina of eye, that's why the FDA encourages people to stop taking drugs like Viagra, and call a doctor right away if you experience sudden loss of vision.According to our classics, texts drug theses works on spermatogenesis also addition works on enhancing both immunity and vision.
Considering the above factors and drawbacks, hindrances of the modern system of medicine an effort has been done to find the treatment therefore it is necessary to find a effective treatment.

Aims & Objectives:
To evaluate the efficacy of Kataka Churna in the management of Male sexual dysfunction & Poor vision.

Methodology:
The study conducted under a strict protocol to prevent bias to reduce the sources of error in the study.This study conducted under the following steps-1.Selection of patients 2. General observation

Administration of drug
The patients for the clinical study were selected from O.P.D. and I.P.D. of NIA Arogyashala Hospital,Roga Nidāna Evam Vikṛti Vijñāna and Shalakya department.Selection carried out based on relevant history, signs, symptoms and laboratory investigations suggestive for the disease Timira (refractive errors).An annexed part of Performa those incorporated with the diagnostic criteria of Timira (refractive errors) with the associated complaints of Male sexual dysfunction (MSD).50patients of Timira (refractive errors) with the associated complaints of Male sexual dysfunction (MSD) registered for the clinical study.
A written in formation and consent form has been given to the selected patients.The patients explained about the purpose, procedures and possible side effects of the trial drugs.
Size of drishtimandala is 1/7 part of krishnamandala i . Drishtikleda = Lubricating fluid of the eyeball ii Drishti in physiological sense: Dr. Shri Ram Saini et al, International Journal of Medical and Biomedical Studies (IJMBS)  Drishtikrishth = Dimness of vision -Kshudhavegadharanat iii . Drishtihanana = Loss of vision.If Adhimantha is not treated properly leads to this condition (prognosis of adhimantha).iv  Drishtivisha = Some immortal Snakes eg.Vasuki has poison in its vision v .