EVALUATING SERUM VITAMIN B12 LEVEL AS THE RISK FACTORS FOR STROKE: A PROSPECTIVE STUDY

Authors

  • Shailendra Singh Senior Residence Medicine, Atal Bihari Vajpayee Government Medical College, Vidisha, Madhya Pradesh, India
  • Chetan Mathur Senior Residence Medicine, Sri Aurobindo Institute of Medical Sciences & PGI, Indore, Madhya Pradesh, India
  • Hritu Singh Associate professor Psychiatry, RKDF Medical College, Bhopal, Madhya Pradesh, India
  • Shahid Abbas Professor, MD Medicine, Sri Aurobindo Institute of Medical Sciences & PGI, Indore, Madhya Pradesh, India

DOI:

https://doi.org/10.32553/ijmbs.v4i4.1100

Keywords:

vitamin B12, stroke, hypertension, diabetes, smoking

Abstract

Background: Hyperhomocysteinemia has been reported to be an independent risk factor for the development of stroke. Vitamin B12 is an important element of homocysteine metabolism.

Aims and Objective: To compare the vitamin B12 level among the groups and compare it with the presence of hypertension, diabetes and smoking status.

Materials and Methods: Ninety subjects were studied in the Department of General Medicine at Sri Aurobindo Medical College and PGI, Indore (M. P.) for one and half year from June-2015 to March-2016 after dividing them in to Cases (n=45; patients of ischemic stroke) and Control (n=45; subjects with no documented stroke). After recording general information on smoking/alcohol habit, hypertension and diabetes status, serum vitamin B12 level was assessed in all the subjects.

Results: Vitamin B12 level (184.98±46.41 picomol/L) was greater in Case group as compared to Control group (639.62±157.43?mol/L) (p<0.001). Amongst those who had a stroke but had a habit of smoking/tobacco, had hypertension and diabetes diagnosed with very lowered vitamin B12 level (199.00±0.00 picomol/L, 176.00±31.21 picomol/L and 152.00±11.31 picomol/L) as compared to those without stroke. Tthose who had a stroke but had mixed diet had much lowered vitamin B12 level (188.71±54.63 picomol/L) as compared to control (592.69±143.71 picomol/L).

Conclusion: Patients with stroke had lower level of vitamin B12 mainly in those with had a habit of smoking/tobacco, had hypertension, diabetes and had mixed diet as compared to those without stroke.

Keywords: vitamin B12, stroke, hypertension, diabetes, smoking

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Published

2020-04-30

How to Cite

Singh, S., Mathur, C., Singh, H., & Abbas, S. (2020). EVALUATING SERUM VITAMIN B12 LEVEL AS THE RISK FACTORS FOR STROKE: A PROSPECTIVE STUDY. International Journal of Medical and Biomedical Studies, 4(4). https://doi.org/10.32553/ijmbs.v4i4.1100

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Research Articles

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