ASSOCIATION OF VITAMIN D AND PARATHYROID HORMONE WITH INSULIN RESISTANCE IN PCOS WOMEN: AN OBSERVATIONAL STUDY
DOI:
https://doi.org/10.32553/ijmbs.v4i10.1517Keywords:
PCOS, Vitamin D, Parathyroid hormone, insulin resistance, HOMA-IRAbstract
Aim: To investigate the relation of vitamin D concentration and parathyroid hormone with insulin resistance in PCOS women.
Methods: This prospective observational study was carried out in the Department of Obstetrics and Gynecology at Government Medical College and Hospital, Bettiah, Bihar, India from September 2018 to February 2020. Concentrations of 25, hydroxyvitamin D and PTH were measured along with serum levels of fasting sugar and insulin.
Results: Total prevalence of vitamin D deficiency (<20ng/ml) was found to be 87% while increased parathyroid hormone level was observed in 67%. There was significant negative correlation between vitamin D deficiency and HOMA-IR (r=-0.64, p<0.01). Positive association was found between increased PTH levels and HOMA-IR.
Conclusion: Vitamin D deficiency and high parathyroid levels are associated with glucose intolerance in PCOS women. Strong correlation between vitamin D deficiency and insulin resistance in PCOS women may suggest that normalization of vitamin D levels may correct insulin resistance.
Keywords: PCOS, Vitamin D, Parathyroid hormone, insulin resistance, HOMA-IR
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