EVALUATING THE EFFECTIVENESS OF ARGON LASER PHOTOCOAGULATION IN SEVERE AND VERY SEVERE NON-PROLIFERATIVE AND PROLIFERATIVE DIABETIC RETINOPATHY
Keywords:Laser photocoagulation, Therapy, Diabetic retinopathy, Diabetic macular edema
Objective: To evaluate the effectiveness of argon laser photocoagulation in patients with severe/very severe non-proliferative and proliferative diabetic retinopathy(DR), who received none of the available intravitreal pharmacological agents.
Material and methods: This clinical study retrospectively examined 771 eyes of 392 patients who received no intravitreal administration of vascular endothelial growth factor (VEGF) inhibitors or corticosteroids for non-proliferative DR (NPDR) and proliferative DR (PDR). The cases comprised 161 (41.07%) male and 231 (58.3%) female patients, with a mean age of 60.4±9.3 (28–90) years. For the patients with NPDR and PDR, panretinal photocoagulation was administered to those without macular edema, and focal or grid photocoagulation to those with macular edema.
Results: The duration of follow-up was a minimum of one year and maximum of 23 years, with a mean of 3.2 ±3.1 years (1-23 years). Five hundred and sixty (72.6%) eyes underwent panretinal photocoagulation and 211(27.4%) eyes panretinal+grid photocoagulation treatment. A comparison of the initial and final visual acuity of patients undergoing laser treatment revealed visual acuity to be increased in 57 (9.3%) eyes, to remain stable in 328 (53.7%) eyes and to decrease in 226 (37.0%) eyes in the NPDR group. In the proliferative group, in turn, it increased in 25 (15.6%) eyes, remained stable in 75 (46.8%) eyes and decreased in 60 (37.6%) eyes.
Conclusion: Laser photocoagulation is an effective treatment method for the treatment of DR in patients not treated with any available intravitreal pharmacotherapy. That said, decreased vision and progressed retinopathy cannot be prevented despite treatment in some patients.
Keywords: Laser photocoagulation, Therapy , Diabetic retinopathy, Diabetic macular edema
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