EVALUATION OF BIOCHEMICAL CHANGES IN TYPHOID PATIENTS OF JAMMU RURAL
Keywords:Typhoid Fever, Salmonella, Serum Glucose, Serum HDL, Serum LDL
Background: Typhoid fever is a bacterial infection caused by bacterium salmonella enteric serotype typhi, which affects only humans. It is frequently endemic in developing countries and may cause very different clinical findings due to poor sanitation and overcrowding. Due to the high mortality rate associated with it, this study was designed to determine the various biochemical parameters in typhoid patients’ serum.
Methods: A case-control study was conducted in the OPD of Community Health Center Katra, Jammu, J&K, from October 2018 to March 2019 on 100 patients and 100 controls with in the age group 25-40 years.
Results: The mean serum glucose concentration in patients was 151.3±12.6 mg/dL and among cases, it was 86.2±10.9 mg/dL. Mean serum LDL, however, was significantly higher in case of patients (126.0±13.1 mg/dL) than controls, which can be attributed to a kind of peroxidation, affecting regular metabolism of lipids and therefore unbalanced delivery of lipids to various organs of the body. Albumin was found significantly higher in typhoid patients, while Globulin levels falling below normal ranges may be indicative of poor protein digestion in the body. Diastolic BP was positively and significantly involved with the patients with Typhoid.
Conclusion: Early detection and diagnosis of typhoid fever and early diagnostic tests measuring the various biochemical and enzyme changes in patients can be a useful tool for typhoid diagnosis, management of patients and control of mortality rate.
Keywords: Typhoid Fever, Salmonella, Serum Glucose, Serum HDL, Serum LDL
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