DRUG INTERACTION AND ADR AMONG THE ELDERLY HYPERTENSIVE PATIENTS IN A TERTIARY CARE HOSPITAL: A CROSS SECTIONAL STUDY

Authors

  • Sumitra Shrestha M.Pharm (Clinical pharmacy) Pokhara University, Assistant Quality Assurance Manager Divine Healthcare Pvt. Ltd. Bharatpur-16
  • Sangit Maharjan B.Pharm Shree medical & Technical College, Production Officer Divine Healthcare Pvt. Ltd. Bharatpur-16
  • Nirmal Raj Marasine M.Pharm (Clinical pharmacy) Lecturere Western Healt Science Academy
  • Sonu Pakhrin M.Pharm (Clinical pharmacy) Pokhara University, Quality Control Officer Divine Healthcare Pvt. Ltd. Bharatpur-16
  • Naresh Thapa B.Pharm Dhaka University Bangladesh, Quality Assurance Manager Divine Healthccare Pvt. Ltd. Bharatpur-16, Nepal
  • Mamita Ghimire M.Pharm (Natural product Chemistry) Pokhara University, Quality Control Officer Kasturi Pharmaceuticals
  • Jeevan Raj Shrestha Medical Officer (M.O.) at Barhabise primary Health Centerand works at Manipal College of Medical Scienses pokhara, MBBS Manipal College of Medical Sciences, Pokhara, Nepal

DOI:

https://doi.org/10.32553/ijmbs.v5i2.1687

Keywords:

elderly, hypertension, Drug-drug interaction, ADRs

Abstract

Objective: This study was conducted to assess the drug interaction and experienced ADRs among the Elderly HTN patients in Tertiary Care Teaching Hospital.

Method: A Quantitative descriptive study of HTN patient’s on drug-drug interactions and experienced ADRs among elderly patient was conducted from May 2018 to November 2018.The face-to-face interview adopted in 332 elderly hypertensive patients with random sampling technique SPSS version 20.0 was used for Data analysis.

Result: the result showed that elderly patients experienced ADRs by (ARB and CCB). The majority 37 (11.14%) and 15(4.15%) were experienced ADR by CCD (Edema in lower limbs) and ARB (Muscle weakness, tiredness) respectively. the prevalence of OTC drug use was found to be 32.53 %. Among the co-morbidity the majority of them had dyslipidemia followed by diabetes in single while in double the higher percentage was found in DM + Dyslipidemia (12 %) followed by COPD+DM (3%)and there was equal percentage of multiple comorbidity 1.2%, in COPD+Dyslipidemia+DM and COPD +CKD+DM. The result showed that the potency of drug-drug interaction among the elderly hypertensive patients was found to be 43.37%, among which 79.38%, 6.18% and 14.43 % were moderate, major and minor respectively. Among the other anthypertensive drug aspirin was the most common interacting drug

Conclusion: The drug-drug interaction among the elderly hypertensive patients was common, although there is limited research on elderly patients, where they are vulnerable group, who need more care for the management of drug and disease related problems. They are at high risk of occurrence of drug interactions and ADRs; there fore the awareness and drug proper management by the clinical pharmacist is required for solving the combination drug related issue in older hypertensive population

Keywords: elderly, hypertension, Drug-drug interaction, ADRs

Downloads

Published

2021-02-19

How to Cite

Shrestha, S., Maharjan, S. . ., Marasine, N. R. . ., Pakhrin, S. ., Thapa, N. ., Ghimire, M. ., & Shrestha, J. R. . (2021). DRUG INTERACTION AND ADR AMONG THE ELDERLY HYPERTENSIVE PATIENTS IN A TERTIARY CARE HOSPITAL: A CROSS SECTIONAL STUDY. International Journal of Medical and Biomedical Studies, 5(2). https://doi.org/10.32553/ijmbs.v5i2.1687

Issue

Section

Research Articles