FINE NEEDLE ASPIRATION CYTOLOGY DIAGNOSIS OF LYMPHOPROLIFERATIVE DISORDERS AND THEIR CORRELATION WITH IMMUNOHISTOCHEMICAL STUDY OF CD3, CD20, CD15 AND CD30 ON CELL BLOCK PREPARATION.
DOI:
https://doi.org/10.32553/ijmbs.v5i5.1908Keywords:
Fine needle aspiration cytology, cell block, lymphomaAbstract
Background: Lymphoma is used for lymphoid neoplasm that present as discrete tissue masses. They are divided into Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Fine needle aspiration cytology (FNAC) sometimes gives false negative interpretation in diagnosis of lymphoma and typing of lymphoma is not possible from FNAC. This can be overcome by cell block (CB) preparation. Histopathological examination is the gold standard in diagnosis of lymphoma and typing of lymphoma is also possible. Lymph node biopsy is associated with complications like lymphedema, allergic reaction to dye and nerve injury. Aim of this study is to correlate cytomorphology on FNAC smears with histomorphology and immunohistochemical findings on the cell block preparation in diagnosis of lymphoma. Materials and Methods: Hospital based calculation study was carried out in Department of pathology in collaboration with Department of Radiation oncology RIMS, Imphal. FNAC was performed on cases clinically suspicious of lymphoma and cell block preparation was also done. Cytomorphological, histo-morphological and immunohistochemical findings were done for all the cases and recorded and analyzed. Results and Observation: Sensitivity, specificity, positive predictive value, negative predictive value and accuracy for the diagnosis of lymphoma were higher for the histo-morphological examination along with IHC study on the CB preparation compared to the FNAC study on the conventional smear preparation. Conclusion: Combined approach along with the IHC study on the CB preparation increases the accuracy in diagnosis of lymphoma and helps in typing of lymphoma as well especially in patients who are at risk for undergoing lymph node biopsy.
Keywords: Fine needle aspiration cytology, cell block, lymphoma
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