EVALUATION OF C-RP AND LIPID PROFILE IN COPD AS A MARKER OF SYSTEMIC INFLAMMATION AND ATHEROGENIC LIPID PATTERN.

Abstract

Chronic obstructive pulmonary disease (COPD), a progressive disease of the lungs characterized by persistent airflow limitation, is one of the main causes of morbidity and mortality worldwide. Epidemiological studies reported that COPD patients have various extrapulmonary comorbidities such as coronary heart disease (CHD), metabolic syndrome, and depression. Extrapulmonary comorbidities increase the risk of hospitalisation and mortality in COPD patients. An increasing number of COPD patients die from systemic comorbidities rather than respiratory failure.  Purpose of present study was to measure serum C-reactive protein (C-RP) and lipid profile in COPD patient to establish its correlation as early predictor of risk factors CHD. Aim: To investigate the levels of  serum C-RP,cholesterol (TCH), triglycerides (TG), low density lipoproteins (LDL), very low density lipoproteins (VLDL), high density lipoproteins (HDL) in COPD patients and correlating FEV1 and FEV1/FVC ratio with lipid profile. Settings and Design: A prospective cross-sectional case control study. Method: 40 COPD patients 33 males (82.5%) and 7 females (17.5%) with mean age of  53.43±9.64 years, FEV1: 52±15 % pred., BMI: 29.4 ±4.5kg/m2 with stable COPD enrolled  in the study. We compared lipid profile in 40 patients with COPD and control group - 40 COPD patients. Results: Mean Cholesterol concentration was (257.30±56.39) (mg/dl), TG (Triglyceride) 253.18±58.98. LDL (191.17±86.17) (mg/dl), VLDL (51.31±11.79), HDL (30.98±5.21) (mg/dl) as against control group who had concentration of 188.58±39.59 (mg/dl), 112.56±55.44, 98.74±28.30, 31.59±11.56, 42.65±6.55 respectively. Which was statistically significant (p-value < 0.001).L/H Ratio (6.59±1.52) in cases compared to control Mean 3.98±1.84.C-RP mean concentration in cases 3.26±2.0, compared to control 0.48±0.38. Conclusion: The study established that there is decreased serum HDL LEVEL and increased cholesterol, TG, LDL, VLDL,L/H, C-RP, BMI in patients with COPD  suggest  C-Reactive Protein (HS-CRP) is considered as a marker of systemic inflammation. Increased LDL, cholesterol levels and decreased HDL cholesterol levels are indicative of an atherogenic lipid pattern.

Keywords: COPD, C-RP, Lipid Profile, Dyslipidemia, Systemic Inflammation