PERIPHERAL NON_ ENZYMATIC ANTIOXIDANTS LEVELS IN SCHIZOPHRENIA AND BIPOLAR ILLNESS A COMPARATIVE CROSS-SECTIONAL STUDY

Abstract

Background: Nervous tissue is extremely sensitive to oxidative damage Recent studies show an elevated level of oxidative stress indicators in Schizophrenia. Current studies on oxidative stress in Schizophrenia mainly focus on enzymatic antioxidants, while limited studies have been carried out on non-enzymatic antioxidants Some studies discovered that plasma non-enzymatic antioxidants (uric acid, bilirubin, and albumin) in Schizophrenia are lower than those of healthy controls.

Aim: To compare levels of nonenzymatic antioxidants in Schizophrenia and bipolar illness.

Material and Methods: The present study is a hospital_ based cross-sectional study conducted among 100 patients with Schizophrenia and Bipolar Affective disorder included as per inclusion and exclusion criteria and undergone psychiatric assessment as per diagnostic criteria.

Results: S. albumin, S.bilirubin, S.uric acid were found to be low in Schizophrenia but statistically, the significant difference was evaluated for S.uric acid.

Conclusion: S. uric acid lower significant levels in Schizophrenia as compared to bipolar affective disorder shows the more impaired peripheral antioxidant scavenging system in Schizophrenia. However, pure peripheral antioxidant system dysfunction could not be ascertained in Schizophrenia through this study.

Keywords: nonenzymatic antioxidants, Schizophrenia, bipolar illness.