TO MEASURE THE INCIDENCE OF TUBERCULOSIS DRUG RESISTANCE IN RE-TREATMENT CASES AND ANALYZES EXPOSURES IN PATIENTS.

Abstract

Background & Method: Present study was conducted with an aim to measure the incidence of tuberculosis drug resistance in re-treatment cases and analyzes exposures in patients. The patient who was diagnosed as a case of Respiratory Medicine sputum positive attending the OPD, IPD and are registered for re-treatment cases at Amaltas Institute of Medical Sciences, Dewas, M.P. A total no of 100 patients of re-treatment cases who gave oral informed consent were registered as subjects. In present study educational status was classified as following Illiterate – Unable to read or write or Able to sign one?s own name.

Result: Pearson Chi-Square = 4.757, DF = 1, P-Value = 0.029, total male subjects – 82. 76.12%: RNTCP group, 93.94%: Non RNTCP group Female subjects- 18. 23.88%: RNTCP group.6.06%: Non RNTCP group.

Conclusion: Our study was carried on subjects who were sputum positive for acid fast bacilli and had a history of taking previous anti tubercular treatment. Drug resistance was identified in our study population as 11% Mono drug & 12% Multi Drug Resistance. Isoniazid [14%] was the most common drug against which drug resistance was identified.

Keywords: tuberculosis, drug resistance & incidence.