Insulin Resistance Associated with Impaired Fasting Glycaemia in Anti-Retroviral Therapy Patients

Authors

  • Karthik K Department of Biochemistry, Armed Forces Medical College, Pune, India-411040
  • Arathi Pillai Department of Biochemistry, Armed Forces Medical College, Pune, India-411040
  • Anurodh Gupta Department of Biochemistry, Armed Forces Medical College, Pune, India-411040
  • Palaniswamy Ramaswamy Multi Disciplinary Research Unit, Armed Forces Medical College, Pune, India-411040
  • Leena Rawat ART Centre, Armed Forces Medical College, Pune, India-411040
  • Sibin M K ART Centre, Armed Forces Medical College, Pune, India-411040

DOI:

https://doi.org/10.32553/ijmbs.v7i6.2711

Keywords:

Human Immunodeficiency Virus, anti-retroviral therapy, impaired fasting glycemia, serum Insulin, HOMA-IR

Abstract

Background: Insulin resistance was associated with type-2 diabetes mellitus regardless of HIV status. However, an association of insulin resistance in prediabetes with HIV-infected subjects undergoing anti-retroviral therapy (ART) has been reported in very few studies.

Methods: Serum insulin and insulin resistance (HOMA-IR) were measured in ART patients with impaired fasting glycemia (IFG) and those with normal glucose tolerance (NGT) along with other biochemical parameters.

Results: There was increased insulin resistance in the ART IFG group when compared to their ART NGT counterparts. There was a positive correlation of HOMA-IR with serum creatinine, triglycerides, and ALT levels. However, serum HDL showed a negative correlation with HOMA-IR.

Conclusion: Present study showed that there is association of insulin resistance in IFG associated with HIV-infected subjects on ART.  Hence, monitoring the insulin resistance in ART patients may help in early prevention of type 2 diabetes mellitus.

Keywords: Human Immunodeficiency Virus, anti-retroviral therapy, impaired fasting glycemia, serum Insulin, HOMA-IR

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Published

2023-06-17

How to Cite

K, K. ., Pillai, A. ., Gupta, A. ., Ramaswamy, P. ., Rawat, L. ., & K, S. M. . (2023). Insulin Resistance Associated with Impaired Fasting Glycaemia in Anti-Retroviral Therapy Patients. International Journal of Medical and Biomedical Studies, 7(6), 24-29. https://doi.org/10.32553/ijmbs.v7i6.2711

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