COMPARATIVE STUDY OF CONCURRENT CHEMORADIOTHERAPY VS RADIOTHERAPY ALONE IN LOCALLY ADVANCED HEAD AND NECK CANCER

Authors

  • Dr. Saroj Dhaka Resident Doctor, Radiation Oncology Department, ATRCTRI, S.P. Medical College, Bikaner
  • Dr. Neeti Sharma Professor and Head, Radiation Oncology Department, ATRCTRI, S.P. Medical College, Bikaner
  • Dr. H.S. Kumar Senior Professor, Radiation Oncology Department, ATRCTRI, S.P. Medical College, Bikaner
  • Dr. S.L. Jakhar Associate professor, Radiation Oncology Department, ATRCTRI, S.P. Medical College, Bikaner
  • Dr. Atul Tiwari Resident Doctor, Radiation Oncology Department, ATRCTRI, S.P. Medical College, Bikaner

DOI:

https://doi.org/10.32553/ijmbs.v3i8.502

Keywords:

Radiotherapy alone, Induction chemotherapy, Unresectable locally advanced head and neck cancer

Abstract

The purpose of the study was to assess difference in the treatment response and toxicity profile  among two groups of unresectable locally advanced head and neck malignancies receiving concurrent chemo-radiotherapy versus radiotherapy alone after completing neoadjuvant chemotherapy.

50 patients received neoadjuvant chemotherapy  (inj. paclitaxel 175 mg/m2 D1 , Cisplatin 80mg/m2 devided in 2 days & inj 5FU 1gm/m2 iv d1&d2).Then randomly allotted into above two groups to receive 66 Gy fractionated RT alone versus  RT along with concurrent 3 weekly inj Cisplatin 80mg/m2 devided in two days. Disease response was evaluated by RECIEST criteria.

All patients tolerated treatment well, no major adverse effects were monitored in two groups. There was no significant statistical difference in treatment response, which was found 88% vs 80% in concurrent CTRT vs RT alone .however toxicity profile was higher in concurrent CTRT group. The 6 months PFS were 83.3% and 78.3% in CTRT and RT alone groups respectively ;(x2=0.196, p value>.05)

Keywords: Radiotherapy alone, Induction chemotherapy, Unresectable locally advanced head and neck cancer.

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Published

2019-08-29

How to Cite

Dhaka, D. S., Sharma, D. N., Kumar, D. H., Jakhar, D. . S., & Tiwari, D. A. (2019). COMPARATIVE STUDY OF CONCURRENT CHEMORADIOTHERAPY VS RADIOTHERAPY ALONE IN LOCALLY ADVANCED HEAD AND NECK CANCER. International Journal of Medical and Biomedical Studies, 3(8), 223-226. https://doi.org/10.32553/ijmbs.v3i8.502

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Section

Research Articles

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