TY - JOUR AU - Soe, Yan Naing AU - Than, Mo Mo PY - 2021/02/20 Y2 - 2024/03/29 TI - SINGLE NUCLEOTIDE POLYMORPHISM IN CORONARY ARTERY DISEASE: IS IT GOOD OR BAD? JF - International Journal of Medical and Biomedical Studies JA - IJMBS VL - 5 IS - 2 SE - DO - 10.32553/ijmbs.v5i2.1697 UR - https://ijmbs.info/index.php/ijmbs/article/view/1697 SP - AB - <p><strong><em>ABSTRACT</em></strong></p><p><strong><em>Introduction:</em></strong> Coronary artery disease (CAD) development and progression were stimulated by environmental or genetic factors. Single Nucleotide Polymorphism (SNP) in apolipoprotein genes involved in lipid and lipoprotein metabolism were primary candidates as susceptibility genes for coronary atherosclerosis.  </p><p><strong><em>Aims and Objectives:</em></strong> Distribution and association of <em>APOA1</em> gene (-75 G&gt;A), and <em>APOC3</em> gene (3238 C&gt;G) polymorphisms with serum lipid parameters in CAD subjects will provide the link between SNP and serum lipid parameters as well as CAD outcome. </p><p><strong><em>Materials and Methods:</em></strong> One hundred and fifty diagnosed CAD patients and one hundred and fifty healthy controls were included. Serum lipid profile was measured and <em>APOA1</em> gene (-75 G&gt;A), and <em>APOC3</em> gene (3238C&gt;G) polymorphism were detected by DNA analysis. Data were analyzed by one-way ANOVA, Chi-square, and Fisher exact tests.</p><p><strong><em>Results:</em></strong> In <em>APOC3 </em>gene (3238 C&gt;G) polymorphism, there was a statistically significant difference in triglycerides between CC (Wild) and CG+GG (Mutant) genotypes (<em>p</em>&lt;0.001) in the dominant genetic model and also statistically a significant difference in triglycerides between CC+CG (Wild) and GG (Mutant) genotypes (<em>p</em>&lt;0.001) in the recessive genetic model.</p><p><strong><em>Conclusion:</em></strong> Results of the present study could help to understand the association of <em>APOA1</em> gene and <em>APOC3</em> gene polymorphism with serum lipid profiles and CAD and further researches were needed to confirm the influence of other contributing factors for the development of CAD.</p><p><strong><em>Keywords:</em> </strong>Polymorphism, Apolipoprotein A1,<em> APOA1</em> gene (-75 G&gt;A), Apolipoprotein C3, <em>APOC3 </em>gene (3238 C&gt;G), Coronary Artery Disease</p> ER -