International Journal of Medical and Biomedical Studies https://ijmbs.info/index.php/ijmbs <p><strong>Aims and Scope</strong></p> <p>International Journal of Medical and Biomedical Studies&nbsp;(IJMBS) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Medical and Biomedical Studies.</p> <p>International Journal of Medical and Biomedical Studies&nbsp;is an academic journal which aims to publish complete and reliable source of information in the field of medical research providing the fundamental knowledge for further research.&nbsp;<em>IJMBS</em>&nbsp;commits to publish the results of researches in medical practice, risk factors and preventive medicine, safety and effectiveness of treatments, and diagnostic tools that are used to treat any disease. Our journal aims to attract an international audience of Medicine professionals enthusiastic to the most updated and substantial medical progress through the full spectrum of medical research.</p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical Studies||&nbsp; Biomedical Studies ||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Anesthesia,<strong>&nbsp;</strong>Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences,&nbsp;Pharmacokinetics,&nbsp;Molecular Drug Design, Phytochemistry, Toxicology, Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology,&nbsp;Agriculture, Herbal Medicine, Orthopaedics and all major disciplines of&nbsp;Medical and Biomedical Studies.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <hr> <p style="text-align: justify;"><strong style="font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif; text-align: justify;">Top Reasons for publication with us</strong></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong style="font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif;">Other features:</strong> DIDS and DOI: Assigned and Implemented the Open Review System (ORS).</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to <strong><span style="color: #008000;">editor@ijmbs.info</span></strong></span></span></p> <hr> <p>&nbsp;</p> en-US editor@ijmbs.info (IJMBS) editorijmbs.info@gmail.com (IJMBS) Thu, 03 Nov 2022 02:46:53 -0400 OJS 3.2.1.1 http://blogs.law.harvard.edu/tech/rss 60 Emergency Treatment of Submandibular Abscess Spreading to Buccal and Submental Spaces in Uncontrolled Diabetic Patients: A Case Study https://ijmbs.info/index.php/ijmbs/article/view/2613 <p><strong>Introduction:</strong> Dental infections can extend to the maxillofacial space causing severe infections such as abscesses. Abscess in the maxillofacial space aggravated by the systemic disease of diabetes mellitus can delay healing and cause further complications. This case report discusses the emergency treatment of a submandibular abscess that extends to the buccal and submental spaces in a patient with diabetes mellitus. <strong>Case Report:</strong> A 41-year-old female patient came to the Emergency Department of Hasan Sadikin Hospital in Bandung, complaining of swelling on the right cheek. The swelling was felt for seven days which started in the right submandibular area and extended to the right cheek and submental area. The patient had a history of diabetes mellitus for eight years, and on arrival, his current blood sugar was 365 mg/dL. The patient was diagnosed with a submandibular abscess that extends to the right buccal and submental area with uncontrolled diabetes mellitus. Treatment includes a drainage incision, Penrose drain, extraction of the causative tooth, and administration of ceftriaxone, metronidazole, ketorolac, and omeprazole drugs. <strong>Conclusion:</strong> Submandibular abscess that extends to several maxillofacial spaces is an emergency condition that requires immediate management to prevent the spread of infection to other tissues, which can cause mortality.</p> <p><strong>Keywords:</strong> Abscess, Submandible, Buccal, Submental, Diabetes Mellitus</p> Cahyono Yudianto, Endang Sjamsudin, Winarno Priyanto, Agus Nurwiadh Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2613 Mon, 07 Nov 2022 00:00:00 -0500 Protective Effects of Sida Veronicaefolia against RIF+INH Induce Hepatotoxicity in Experimental Animals https://ijmbs.info/index.php/ijmbs/article/view/2628 <p>In the current research, rats will be given RIF+INH (hepatotoxic), and the hydoethanol (HEESV) extract of the leaves of Sida veronicaefolia will be tested to see how well it protects the rats' livers from damage caused by the RIF+INH. Liver function tests and serum profiles were used to provide an estimate of the hepatoprotective effects of HEESV at a dose of 500 mg/kg. According to the findings, the extracts of Sida veronicaefolia not only provide a strong hepatoprotective impact by lowering blood levels of serum transaminases (SGPT and SGOT), alkaline phosphate, and total bilirubin, but they also considerably enhance the levels of total protein. The effects of HEESV were quite similar to those of the standard medication silymarin.</p> Vidhi Jain, Ajay Kumar, Shilpi Mishra, Manmeet Singh Saluja Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2628 Wed, 16 Nov 2022 00:00:00 -0500 Evaluation of Hepatoprotective Activity of Aqueous Extract of Nyctanthes Arbortristis Bark against Paracetamol-Induced Liver Damage https://ijmbs.info/index.php/ijmbs/article/view/2621 <p>Herbal drugs aimed to determine the hepatoprotective activity of aqueous extract of <em>Nyctanthes arbortristis</em> bark (AQENA) against paracetamol-induced liver damage (PILD) in rat models. Four groups of rats (n=6) were givens one daily administration of 1gm/kg (negative control), 25mg/kg silymarin (positive control) and AQENA (500mg/kg) for 7 days fallowed by induction of hepatotoxicity using of paracetamol. Various parameters, such as physical parameters, biochemical parameters and microscopic analysis ware used to evaluate the hepatoprotective activity. Results indicate that bark extract would a significant (p&lt;0.05) hepatoprotective activity against inducers. These observations were supported by the histological finding. Conclusions: Findings indicate that AQENA possesses a potent hepatoprotective activity against paracetamol.</p> Ajay Kumar, Dr. Manmeet Singh Saluja, Shilpi Mishra, Arti Pandey Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2621 Sun, 13 Nov 2022 00:00:00 -0500 Comparative Evaluation of Injectable Platelet Rich Fibrin (I-PRF) with DFDBA and Titatium Prepared Platelet Rich Fibrin (T-PRF) with DFDBA In The Treatment of Infrabony Defects In Chronic Periodontitis Patients - A Clinico-Radiographical Study https://ijmbs.info/index.php/ijmbs/article/view/2630 <p><strong>Objectives:</strong> The main objective of this study was to evaluate the efficacy of Titanium prepared platelet-rich Fibrin (T-PRF)&nbsp; and Injectable Platelet Rich Fibrin (I-PRF) with demineralized freeze-dried bone allograft (DFDBA) in order to improve the clinical and radiographic results obtained in treatment of periodontal infrabony defects.</p> <p><strong>Materials and Methods: </strong>This&nbsp; split-mouth randomized controlled clinical trial was conducted on 30 subjects with two comparable bilateral infrabony defects. Plaque Index(PI), Gingival Index(GI) Clinical attachment level (CAL), Periodontal Pocket depth (PD), as well as radiographic parameters IOPA including the radiographic defect size,&nbsp; were measured at six months post-operatively.</p> <p><strong>Results: </strong>The mean reductions in PD and CAL were 4.0±0.77 mm and 2.5±0.68 mm in sites treated with I-PRF+DFDBA, respectively (P&lt;0.05); these reductions were 4.2±0.86 mm and 3.1±0.62 mm, respectively in T-PRF+DFDBA group (P&lt;0.05). Radiographic evaluation revealed reduction in the radiographic defect size in the I-PRF+DFDBA and T-PRF+DFDBA sites. Statistically, there were no significant differences between the two treatment modalities.?</p> <p><strong>Conclusion:</strong> This study showed that both treatments resulted in significant improvement in the probing depth reduction, clinical attachment level gain and radiographic size of the infrabony defect at six months after surgery. I-PRF with DFDBA membrane in treatment of infrabony osseous defect showed more defect fill followed by T- PRF along with DFDBA membrane.</p> Bushra Shams, Prerna Kataria, Pradeep Sukla, Mona Dagar Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2630 Tue, 29 Nov 2022 00:00:00 -0500 In-Vitro Antioxidant and Anti-Neoplastic Activity of Leaves Extract of Adina Cardifolia https://ijmbs.info/index.php/ijmbs/article/view/2622 <p>This study of the antioxidant properties of Adina cardifolia ware successfully investigated using DPPH radical scavenging, nitric oxide radical scavenging, Superoxide anion radical scavenging, total antioxidant activity by ABTS*+ radical scavenging and lipid peroxidation inhibitor assays and compared with the standards. Also the anti-neoplastic activity was study by MTT assay using MCF7 Cell line. Percentage growth inhibition by MTT assay using MCF-7 cell line ware found to be 65.54±1.05 by PEAC extract respectively compared to 83.03±1.0% by standard drug Methotrexate.</p> Shilpi Mishra, Ajay Kumar, Vidhi Jain, Dr. Manmeet Singh Saluja Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2622 Sun, 13 Nov 2022 00:00:00 -0500 Marfan’s Syndrome https://ijmbs.info/index.php/ijmbs/article/view/2618 <p>Marfan’s syndrome is a congenital anomaly characterized by disorders of the connective tissue manifested principally by changes in skeleton, ocular and cardiovascular manifestation.</p> Dr Mohd Tajuddin, Dr Basavaraj R Puranik, Dr B. Prahalad Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2618 Thu, 10 Nov 2022 00:00:00 -0500 Characteristics of Midfacial FractureIn Oral and Maxillofacial Surgery Department at Hasan Sadikin General Hospital https://ijmbs.info/index.php/ijmbs/article/view/2626 <p><strong>Objective</strong>: Maxillofacial trauma is a physical trauma of hard and soft tissues of the face. Midfacial fractures cause functional failure, facial asymmetry, and decreased quality of life. The incidence of fractures was high because of the anatomical configuration of prominent bones. The aim was to determine the characteristics of midfacial fractures at the Oral and maxillofacial surgery department RSHS Bandung from January – December 2019</p> <p><strong>Materials and Methods</strong>: This is a quantitative descriptive retrospective study with samples of all midfacial fractures from the total population of oromaxillofacial trauma at the Oral and maxillofacial surgery department RSHS Bandung from January - December 2019.</p> <p><strong>Results</strong>: 166 patients with maxillofacial trauma, there were 78 patients with midfacial involvement with the most fracture locations in the zygoma 64.103%, the most complex fractures were Le Fort-2 fractures 11.54 %, the majority of trauma isolated in the midfacial 53% and 47% accompanied by trauma from another region, the most accompanied by trauma to the mandible bone by 34.62%.</p> <p><strong>Conclusion</strong>: Zygoma fracture was the most common fracture due to the anatomical configuration of the prominent midfacial bone</p> <p><strong>Keywords</strong>: Trauma, fracture, midfacial</p> Rani Septikasari, Melita Sylviana, Lucky Riawan Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2626 Sat, 26 Nov 2022 00:00:00 -0500 CHARACTERISTICS OF PATIENTS WITH ODONTOGENIC INFECTION AT dr. HASAN SADIKIN GENERAL HOSPITAL DURING COVID-19 PANDEMIC https://ijmbs.info/index.php/ijmbs/article/view/2617 <p><strong>ABSTRACT</strong></p> <p><strong>&nbsp;</strong></p> <p><strong>Introduction : </strong>Odontogenic infection is one of the most common infections in the oral cavity. Odontogenic infections will spread through three stages; dentoalveolar stage, spatial stage, and a further stage which is the complication stage. There was a tendency to delay dental treatment due to suppress the number of COVID-19 infection, therefore it was interesting to study the characteristic of patients suffering odontogenic infections in the Oral Surgery Department of dr. Hasan Sadikin General Hospital during the COVID-19 pandemic.</p> <p><strong>Methods </strong>: The sample in this study were patients diagnosed with odontogenic infection at the Inpatient Installation of dr. Hasan Sadikin General Hospital during the COVID-19 pandemic from March 2020 – August 2021, 66 patients met the inclusion criteria. This research was conducted using total sampling. This research is a retrospective descriptive study using medical records of patients diagnosed with odontogenic infections.</p> <p><strong>Results</strong>: Based on the age, most of the odontogenic infection patients were over 48 years old, with 29 people. Based on the gender criteria, most of them were male, with a total of 45 people. Based on the occupation criteria, most of them were entrepreneur, with a total of 21 people. Based on the education criteria, most of them were at the senior high school level, with 41 people. Based on the ethnicity, most of them were Sundanese, with a total of 65 people. Based on the marital status criteria, most of them were married, with 58 people. Based on the spatial involvement mostly with 3 spatial involvement with 24 people. Based on the length of stay criteria, most of them stayed for 1-2 days with a total of 19 people. Particularly based on the COVID-19 status, most of them were COVID-19 negative about 61 people.</p> Reiner Avelino Simarmata, Winarno Priyanto, Andri Hardianto Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2617 Thu, 10 Nov 2022 00:00:00 -0500 The prevalence of maxillary fractures at Hasan Sadikin Hospital Bandung between 2015 and 2020 https://ijmbs.info/index.php/ijmbs/article/view/2627 <p><strong>Abstract</strong><strong>Introduction</strong>: Maxillofacial trauma includes injuries to the lower, middle, or upper thirds of the face and oral cavity. As these fractures have the potential to cause morbidity and even mortality, they require careful examination and management based on their severity. This study aimed to provide information regarding the number and types of maxillary fracture cases at Hasan Sadikin General Hospital, Bandung. <strong>Methods</strong>: The design of this study was a descriptive study. Patients diagnosed with unilateral maxillary fractures, palatal fractures, Le Fort I fractures, Le Fort II fractures, and Le Fort III fractures admitted to Hasan Sadikin Hospital, Bandung, from January 2015 - December 2020, were included. Patients with incomplete medical records were excluded from this study.<strong>Results</strong>: This study found 157 maxillary fracture patients out of 1221 maxillofacial trauma patients treated at the Oral and Maxillofacial Surgery Department of Hasan Sadikin General Hospital between January 2015 and December 2020. Male patients had a more significant number of cases (87.26%). The ages 11 to 20 years had the highest incidence of maxillary fractures (29.29%). Maxillary fractures accompanied by palatal fractures were the most prevalent, followed by Le Fort II fractures and unilateral maxillary fractures (28.66%, 21.01%, and 11.46%, respectively). About 42.67% of patients who experienced maxillary trauma also sustained mild head injuries. The most frequent mechanism of injury was motor vehicle accidents (95.54%).<strong>Conclusion: </strong>This study reported the prevalence of maxillary fractures at Dr. Hasan Sadikin Bandung between 2015 and 2020 based on fracture types, sex, age groups, head injuries, and mechanism of injury. Future study is required to measure the force, direction, impact mechanism, use of helmets, and types of helmets to prevent maxillofacial trauma.</p> <p>Keyword : Maxillary fracture, le fort I, le fort II, palatal fracture</p> Fauzan Akmal, Agus Nurwiadh, Winarno Priyanto Copyright (c) 2022 International Journal of Medical and Biomedical Studies http://creativecommons.org/licenses/by/4.0 https://ijmbs.info/index.php/ijmbs/article/view/2627 Thu, 24 Nov 2022 00:00:00 -0500