This combined extract is used in traditional medicine for the treatment of psychiatric disorder. This study investigated the effect of combined crude extracts of Costus afer, Culcasia scaden and Sarcocephalus latifolius on neurobehaviour and histology of the temporal lobe. The extract was prepared by mixing equal portions of the three extracts and dosage calculated base on the body weight of the animals. Twenty rats were divided into four groups (n=5) such as A, B, C and D. A served as negative control and was given distilled water. The D group served as positive control and received 2.5mg/kg of Diazepam, while B and C served as the experimental group and received 100mg/kg and 150mg/kg respectively for 14 days. The behavioural assay was carried out using elevated plus maze. The animals were sacrificed and the brains removed and processed using normal histological techniques. The result of the behavioural test showed an increase in close arm entry but when compared to the negative control the extract treated groups made more open arm entry and spent more time in the open arm (open arm activity) but less when compared to positive control (Diazepam). This is a measure of anxiolytic activities of the extract. Therefore the extract possesses anxiolytic property. The extract distorted the histoarchitecture of the temporal lobe showing extensive loss of brain tissues, sparsely dispersed cells, and focal loss of brain tissues at doses of 100mg/kg and 150mg/kg respectively. The extracts conclusively possess the potential to modify neurobehaviour and alter the histology of the temporal lobe.