EVALUATION OF THE ENDOMETRIAL CHANGES IN FEMALES DIAGNOSED WITH THE UTERINE LEIOMYOMAS

Abstract

The female genital tract includes the uterine corpus and cervix. The uterus consists of the endometrium and myometrium which are continuously stimulated by hormones, denuded monthly of its endometrial mucosa and inhabited periodically by foetuses. Together with the lesions that affect the cervix, the lesions of the corpus of the uterus and the endometrium account for most patient visits to gynaecologists. Many treatment options are available nowadays including medical and conservative surgical procedures. Hence based on above findings the present study was planned for Evaluation of the Endometrial Changes in Females Diagnosed with the Uterine Leiomyomas.

The present study was planned in Department of Obstetrics and Gynaecology, Madhubani Medical College and Hospital, Madhubani, Bihar. In the present study 50 cases of the females diagnosed with the uterine leiomyomas were enrolled. Gross examination was performed with respect to size and  weight of uterus, location of fibroids and endometrial polyp if any was noted. Tissue bits from the fundic endometrium, tissue from both sides of endometrial canal & endometrium subjacent to sub mucosal leiomyoma were taken for histopathological examination, processed and sections of 5 micron thickness stained with haematoxylin and eosin.The data generated from the present study concludes that Different patterns are seen in the endometrium of leiomyomatous uteri as a result of mechanical or hormonal factors such as dilated/ distorted glands, glands parallel to long axis of myometrium, glands separated by muscle fibres, focal total or subtotal glandular atrophy and polyposis which are statistically significant in identifying uterine leiomyoma. Further, total and subtotal endometrial glandular atrophy showed significant association with submucosal leiomyoma.

Keywords: Leiomyoma, Endometrium, Menorrhagia, etc.