A COMPARATIVE STUDY OF SERUM AND SALIVARY BIOCHEMICAL MARKERS IN DIABETES MELLITUS TYPE II WITH HEALTHY INDIVIDUALS

Abstract

Introduction: Blood is the gold standard body fluid for diagnosis of Diabetes Mellitus (DM) but saliva can offers an alternative to serum as a biological fluid for diagnostic purposes because it contains serum constituents. People wants that medical science should promote non invasive method for diagnosis of disease.

Aim: The study was conducted to estimate and compare serum and salivary glucose, total protein, calcium and phosphorus levels in DM type ll and healthy subjects and to evaluate whether saliva can be used as a diagnostic fluid in DM type ll patients. The target population of this study was individuals who have Type-2 DM for different period of time and resident INDORE.

Materials & Methods: Study consisted of 50 subjects from OPD/IPD Index Medical College & Research Center, INDORE, MADHYA PRADESH, India. The study groups were divided into Group I-25 DM patients (TypeII) and Group II-25 healthy subjects. The saliva and serum samples were collected from each subject and levels of different biochemical parameters were estimated.

Result: were noted. On comparing values in saliva and serum, among two groups, a significant difference (p<0.005) was found between few of them.

Conclusion: Values regarding blood and salivary biochemical parameters were distinctly different between two groups suggesting salivary parameters can be used as a diagnostic alternative to blood parameters for diabetes mellitus.