A COMPARATIVE STUDY BETWEEN ETOMIDATE AND PROPOFOL AS AN INDUCTION AGENT DURING INDUCTION, LARYNGOSCOPY AND INTUBATION

Abstract

Background: The objective of study was to compare Etomidate and Propofol as induction agents and their effect on Pain on injection, time to loss of consciousness and myoclonic movements.

Methods: The study was carried out on 100 patients of ASA grade I and II between 18-58yrs of age of either sex enrolled for this prospective randomized double blind study, admitted in K D Medical College, Hospital & Research Center, Mathura  (U.P) and scheduled for elective surgical procedures under general anaesthesia and endotracheal intubation.

Results: The incidence of pain on injection in propofol group was more as compared to etomidate group (p value <0.05). In propofol group 25(50%) patients while in etomidate group only 2(4%) patients had pain on injection. Etomidate group had significantly more myoclonic movements than propofol group (p value <0.05). In etomidate group 18(36%) patients had myoclonic movements of various severity, while in propofol group no patient had myoclonic movements.

Conclusion: Incidence of apnoea on induction was more in propofol group than etomidate group but comparison was not statistically significant.

Keywords: Apnea, Propofol, Etomidate.