TO EVALUATE THE INCIDENCE OF DRUG RESISTANCE IN TUBERCULOSIS RE-TREATMENT PATIENTS AND ANALYZES THE PATTERN.

Abstract

Background & Method: The patient who was diagnosed as a case of Pulmonary Tuberculosis sputum positive attending the OPD, IPD of Respiratory Medicine of Sapthagiri Institute of Medical Sciences & Research Center, Bangalore, Karnataka. Physical Examination was done on Complete haemogram, Erythrocyte Sedimentation Rate, Sputum for Acid Fast Bacilli (2 samples), Sputum for Acid Fast Bacilli Culture & Sensitivity.

Result: An insignificant association between type of drug resistance and reason for registration such as defaulter, relapse and failure that concluded satisfactory insignificant (p>0.05) is detected among studied subjects.  Maximum no. of cases was found in Isoniazide resistance observed in a total subject of 14 subjects out of which 18(18.75%) defaulter, 10(12.82%) case of relapse.

Conclusion: Drug resistance was identified in our study population as 11% Mono drug & 12% Multi Drug Resistance. Isoniazid was the most common drug against which drug resistance was identified. High prevalence rate of drug resistance, we recommend that in all freshly diagnosed cases of Pulmonary Tuberculosis, the anti tubercular treatment as recommended by RNTCP should be started immediately but before starting the treatment the sputum for AFB Culture & Sensitivity should be sent.

Keywords: Tuberculosis, resistance, re-treatment & drug.