SINGLE NUCLEOTIDE POLYMORPHISM IN CORONARY ARTERY DISEASE: IS IT GOOD OR BAD?
Introduction: Coronary artery disease (CAD) development and progression were stimulated by environmental or genetic factors. Single Nucleotide Polymorphism (SNP) in apolipoprotein genes involved in lipid and lipoprotein metabolism were primary candidates as susceptibility genes for coronary atherosclerosis.
Aims and Objectives: Distribution and association of APOA1 gene (-75 G>A), and APOC3 gene (3238 C>G) polymorphisms with serum lipid parameters in CAD subjects will provide the link between SNP and serum lipid parameters as well as CAD outcome.
Materials and Methods: One hundred and fifty diagnosed CAD patients and one hundred and fifty healthy controls were included. Serum lipid profile was measured and APOA1 gene (-75 G>A), and APOC3 gene (3238C>G) polymorphism were detected by DNA analysis. Data were analyzed by one-way ANOVA, Chi-square, and Fisher exact tests.
Results: In APOC3 gene (3238 C>G) polymorphism, there was a statistically significant difference in triglycerides between CC (Wild) and CG+GG (Mutant) genotypes (p<0.001) in the dominant genetic model and also statistically a significant difference in triglycerides between CC+CG (Wild) and GG (Mutant) genotypes (p<0.001) in the recessive genetic model.
Conclusion: Results of the present study could help to understand the association of APOA1 gene and APOC3 gene polymorphism with serum lipid profiles and CAD and further researches were needed to confirm the influence of other contributing factors for the development of CAD.
Keywords: Polymorphism, Apolipoprotein A1, APOA1 gene (-75 G>A), Apolipoprotein C3, APOC3 gene (3238 C>G), Coronary Artery Disease
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