CUTANEOUS ADVERSE DRUG REACTIONS IN TERTIARY HOSPITAL (ADVERSE DRUG REACTION OF CUTANEOUS IN TERTIARY CARE HOSPITAL: A RETROSPECTIVE STUDY.)

Abstract

Introduction:  The term “adverse drug reaction" is defined as the noxious response that occurs due to administration of a drug and this response is resulted when the drug is administered within the permissible dose intended for prophylactic, therapeutic or diagnostic purpose of a disease. About 30% of adverse drug reactions (ADR) appear as cutaneous form. The developed countries (in-patient incidence 1-3%) in comparison developing nations (2-5% in same category) report lesser cases of cutaneous ADR.

Objectives: The study intends to find incidence of cutaneous adverse drug reactions in a tertiary care hospital and the responsible classes of drug.

Materials and Methods: This retrospective study has considered 50 patients. the records of the patients were obtained from the hospital record and the type of ADR and the drugs each patient used, were obtained and evaluated.

Result: the study has found that most common ADR is maculopapular rash, contributing to 32% of the total patients which is followed by other cutaneous ADR like are to urticaria, exfoliative dermatitis and eczematous eruption. The study has also found that the most common cutaneous ADR causing classes of drug is the anti-microbials, followed by NSAIDs and steroids.

Conclusion: Cutaneous ADR should be well known by the clinicians, it can be tackled at right time and hence can be minimized. Antimicribials, NSAIDs and steroid managements should be taken care as they cause ADR the most often. Swift detection and appropriate response are essential to minimize the burden of the management.

Keywords: adr, cutaneous, drug reactions, antimicrobials