EFFECT OF CURCUMIN ON SIDE EFFECTS OF CHEMOTHERAPY AS ASSESSED BY COMPLETE BLOOD COUNTS, R.F.T., L.F.T. IN PATIENT OF HAEMATOLOGICAL MALIGNANCIES AND SOLID TUMOURS

Abstract

Background: Effect of curcumin on side effects of chemotherapy as assessed by complete blood counts, R.F.T., L.F.T.  in patient of haematological malignancies and solid tumours.

Methods: The study population consisted of male and female patients of Haematological Malignancies & patient of solid tumours (stage 3 & 4 lung, breast, head & neck, ovary Cancer) selected from patients attending medical, radiotherapy and Birla Cancer OPD and medical in-patient wards.

Results: Comparing of total leucocyte count, absolute neutrophil count and platelet count of group A1 and B1 at 1, 2, 3, 4, 8, 12, 16, 20 and 24 weeks, there is no significant difference found. Comparing of total leucocyte count and platelet count of group A2 and B2 at 4, 8, 12, 16, 20 and 24weeks, there is no significant difference found.

Conclusion: No dose-limiting toxicities were seen in group-A for curcumin. Derangement of liver function tests occurred in 1 (5%) patients from group-A1 and 2 (10 %) patients from group-B1. No renal toxicity was encountered in group-A1 and B1.

Keywords: Neutrophil, Leucocyte, Haemoglobin