TO EVALUATE THE EFFECT OF TOPICAL 2% REBAMIPIDE OPHTHALMIC SUSPENSION IN PATIENTS WITH DRY EYE DISEASE.

Abstract

Background: Dry eye is an important public health problem causing ocular discomfort, fatigue and visual disturbance that may interfere with daily activities

Methods: It is a prospective, randomized, analytical hospital based study. Minimum Sample size of 80 patients which is randomly allocated in the study (cases) and control group.  In the study group topical 2% rebapimide ophthalmic suspension and in control group 0.5% caboxymethyl cellulose ophthalmic solution were given after comprehensive ophthalmic evaluation.

Results: In mild OSDI score chi square test showed p value as 0.07 which was statistically not significant. In moderate OSDI score chi square test showed p value as 0.07 which was statistically not significant.  In severe OSDI score chi square test showed p value as 0.04 which was statistically significant.

Conclusion: Rebamipide 2% ophthalmic suspension is an effective treatment in dry eye disease due to mucin deficiency. There was significant improvement in signs and symptoms of dry eye

Keywords: OSDI, Dry eye, Rebamipide 2% ophthalmic suspension