A RARE CASE STUDY OF MEDULLARY CARCINOMA OF DESCENDING COLON REPORTED ON HISTOPATHOLOGY

Abstract

Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer which characterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate. This has now been incorporated as a separate entity in the World Health Organization (WHO) classification of colorectal cancers. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge¹.

Keywords: medullary carcinoma, colorectal carcinomas (CRC), medullary carcinoma of colon, poorly differentiated adenocarcinoma, undifferentiated adenocarcinoma.