STUDY OF COMPARATIVE OUTCOME OF 0.5% BUPIVACAINE AND 0.5% BUPIVACAINE WITH CLONIDINE (50µg) FOR SPINAL ANAESTHESIA

Abstract

Background: bupivacaine is the most commonly used drug for spinal anesthesia.  To improve upon the quality of analgesia and prolong the durationof its  action,  many adjuvants have been tried. Intrathecal clonidine an ?2 adrenceptor agonist  has potent central antinoceptive properties withanalgesic effect at  spinal  level mediated by postsynaptically situated  adrenoreceptor  in  dorsal  horn  of  spinal cord.

Material and Methods: 100 ASA grade I/II patients aged between 18-60 years undergoing elective lower  abdominal, urologic,  lower limb  surgeries  were selected and divided into two groups of 50 each. Bupivacaine Group B received intrathecally 2.5 mL of heavy Bupivacaine+0.5mLnormal saline, whereas clonidine Group BC received intrathecal 2.5 mL of heavy Bupivacaine with 50 µg clonidine.(total 3mL).

Conclusion: Clonidine potentiates bupivacaine spinal anesthesia by increasing the duration and improving the quality of analgesia without significanthemodynamic side effects and with mild sedation.

Keywords: Spinal anesthesia, Clonidine, Bupivacaine, Complete and effective analgesia.