SERODIAGNOSIS OF DENGUE VIRAL INFECTION WITH PLATELET COUNT CORRELATION IN PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL

Abstract

Background: Dengue viral infection is an arboviral infection transmitted by Aedes mosquito more common in children than adults is widely distributed in India can cause serious complications such as Dengue haemorrhagic fever(DHF)&dengue shock syndrome(DSS) there is no effective vaccination for dengue fever early detection  is important in the management of dengue fever.

Aims & objectives: Serodiagnosis of dengue viral infection with platelet count correlation in patients presenting to a tertiary care hospital

Material and Methods: A retrospective study of Dengue serology and platelet count of patients blood samples collected in central lab from over the period of two years was done at a medical college in Central India.

Results: Of the 1506 patient samples tested 524 were tested Positive for either NS1, IgM and IgG, of the 524 samples NS1 positive only were 276 (52.67 %) followed by IgM positive only 114 (21.75 %), IgG positive only 10 (1.90%) NS1 and IgM positive only 112 (21.37%), NS1 and IgG positive only 2 (0.38%), IgG and IgM positive only 10 (1.90%). Platelet count less than 1 lakh was seen in 280 patients, In NS1 positive patients 134 (48.55%) had thrombocytopenia followed by IgM only positive patients 80 (70.18%) IgG only positive 10 (100%), NS1 and IgM positive only 44 (39.29%), NS1 and IgG positive only 2 (100%) and IgG and IgM positive only 10 (100%) had thrombocytopenia.

Conclusion: NS1 antigen remains important in the detection of dengue viral infection as maximum number of dengue fever in this study were detected by NS1 antigen and largest group of patients having thrombocytopenia were associated with NS1 antigen detection Out of 276 total NS1 positive cases thrombocytopenia was seen in 90 patients.

Key Word: dengue, platelet count, haemorrhagic fever.