Dry Eye and Antipsychotic Drug

Abstract

Background: To study the dry eye prevalence in patients on chronic antipsychotic therapy.

Methods: 50 patients who were diagnosed of schizophrenia and have been under anti-pschyotic were included. 

Results: 17 patients out of 50 patients on anti-psychotic medications for more than 2 years had dry eye disease. Of the 100 eyes evaluated, 30 eyes were found to have dry eye disease. Patients on two drug regimen showed more prevalence of dry eye than on mono drug regimen in our study.

Conclusion: Anti-psychotic drug may induce dry eye syndrome and thus may lead to morphological alterations in corneal parameters through its anticholinergic and antidopaminergic activities.

Keywords: Dry eye, Prevalence, Antipsychotic