EVALUATION OF INTRACRANIAL SPACE OCCUPYING LESIONS BY CT PERFUSION STUDY

Abstract

Introduction: CT perfusion plays an invaluable role here as it detects microscopic differences in the internal vascularity of lesions and aids in their characterisation and significantly raises the diagnostic accuracy. In this Retrospective study, we performed CT Perfusion in various intracranial focal lesions and studied their perfusion characters and tried to evaluate & differentiate between them.

Methods: This Retrospective Analytical  study involved data of 100 of the randomly selected patients ( candidates / study subjects .CTP was performed with dual?slice dynamic multi?detector CT scanner in 100 patients prior to surgery or stereotactic biopsy with age ranging from 15 to 70 years. Patients below 15 years, pregnant women, and very old patients with compromised renal functions were not included in this study. It was noted that Informed consent was taken from all patients .

Results: Perfusion parameters like rCBF and rCBV were calculated with ROI including the whole of the lesion and 1?2 cm in the periphery of the lesion. The rCBF and rCBV of neoplastic lesions with statistically significant difference in rCBF and rCBV of low?grade gliomas from high?grade gliomas, lymphomas, and metastases.There was statistically significant difference in rCBF (P < 0.002) and rCBV (P < 0.001) of TWT, TOT, and abscesses.

Keyword: ICSOL , CT Perfusion , Cerebral blood flow , Cerebral blood volume.