In Silico Phytochemical Screening for Dengue Virus

Abstract

By and by, the world is fighting with dengue for long decades.  However, the pathogenesis of dengue has not yet been fully elucidated. Dengue fever is a virus infection that is spread by the Aedes aegypti mosquito and can cause severe disease especially in children. Dengue fever is a major problem throughout the world especially tropical and sub-tropical regions of the world.The disease is still tearing down the world. Millions of researchers are still continuing for the potential medication up-and-comer that could help the medical care framework to keep world health. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Gingerol, Honokiol, Thiosulfinate, Saponin, Coumarin, Apigenin, Limonin, Baicalin, Quercetin, Tannin amine, Ajoene, Curcumin, with proteins with PDB id’s 4OIG, 6VSO could display antiviral activity against destructive dengue virus. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against Dengue virus.