In Silico Phytochemical Screening for Hantavirus

Abstract

Several rodent species are carriers of hantavirus which are present throughout the world. Hantavirus was a group of unknown class of viruses which was first seen in the United States of America in 1993 as  an acute respiratory disease now termed hantavirus pulmonary syndrome (HPS). Earlier  HPS hantavirus were known as the agents of hemorrhagic fever with renal syndrome which was seen in eastern hemisphere of the world .A lot of research is going around in and around hantavirus Their ubiquity and potential for causing severe human illness make these viruses an important public health concern.We present a docking based screening using a quantum mechanical  scoring of a library built from approved drugs and compound that limonin ,curcumin, luteolin, rutin, Baicalin, Quercetin, Resveratrol, Kaempferol, Naringenin, Atropine, 4 Hydroxy Coumarin, Colchicine, Thymoquinone, Glabridin ,Hypericin, Lycorine with proteins having PDB id’s 5E04 and 5E05 could display that the phytochemicals can act against Hantavirus. We hope that our findings may contribute to rational drug design against Hantavirus.