TO COMPARE THE EFFECTIVENESS OF DIFFERENT REGIMEN IN MANAGEMENT OF DERMATOPHYTE INFECTION AT TERTIARY CARE CENTER BIKANER RAJASTHAN
Keywords:Fluconazole, Griseofulvin, Mono Therapy, Dual therapy, Tinea Cruris and Tinea Corporis
Background: The dermatophytoses are caused by a group of fungi known as ringworm or Tinea. These are from genera Microsporum, Trichophyton and Epidermophyton. Amongst Five to six species which are prevalent globally, Trichophyton rubrum happens to be the commonest.
Methods: A hospital based comparative prospective study included 600 patients of dermatophytoses having Tinea cruris and Tinea corporis attending the outpatient department of Dermatology, Venereology and Leprosy in PBM hospital Bikaner. Patients randomly divided into 3 groups - Group A received Tablet Fluconazole 150 mg per week plus Tablet Griseofulvin 10mg per kg bodyweight daily in two divided doses. Group B received Tablet Fluconazole 150 mg per week. Group C received Tablet Griseofulvin 10mg per kg body weight in two divided doses daily. Treatment to all groups was given for a period of 4 weeks. The data were analyzed on EPI-Info-6 Software.
Results: There were no statistically significant difference noted among three groups at 1st, 2nd & 3rd weeks and statistically significant difference in three groups was observed at 4th & 8th weeks follow-up.
Conclusion: The combination of Fluconazole and Griseofulvin is a bettar treatment option to treat tinea cruris and corporis as compared to mono therapy with Fluconazole or Griseofulvin.
Keywors: Fluconazole ,Griseofulvin, Mono Therapy, Dual therapy, Tinea Cruris and Tinea Corporis.