Hypoglycemic Activity Nyctanthes Arbor­Tristis LINN. IN Alloxan Induced Diabetic Rats

Abstract

Medical science still faces difficulties in developing side-effect-free medications for diabetes management. This has increased the need for safe and effective natural remedies that may lower blood sugar levels. The purpose of this study is to determine whether or not an ethanolic extract of Nyctanthes arbor­tristis Linn. leaves reduces blood sugar levels in alloxan-induced diabetic albino rats. Nyctanthes arbor­tristis Linn. Ethyl Acetate extract activity was compared to that of the glibenclamide (0.5mg/kg p.o.) standard antidiabetic medication. Normal rats were given oral dosages of an Ethyl Acetate extract of Nyctanthes arbor­tristis Linn. leaf. At a dosage of 200 mg/kg, the Ethyl Acetate extract was significantly (p0.05) hypoglycemic. Leaves extracted with ethyl acetate from the Nyctanthes arbor­tristis linn plant have anti-diabetic effects on a par with those shown in diabetic control mice. Nyctanthes arbor­tristis linn leaf extract in ethyl acetate has been shown to have potent and non-toxic anti-diabetic properties.