IMPACT OF ANTIEPILEPTIC DRUGS ON VITAMIN D STATUS IN CHILDREN WITH EPILEPSY: A CLINICAL STUDY

Abstract

Background: Epilepsy is a prevalent neurological disorder in children, often necessitating long-term treatment with antiepileptic drugs (AEDs). These medications have been associated with altered metabolism of vitamin D, potentially leading to deficiencies that may affect bone health and overall well-being.

Objective: This study aims to evaluate the change in vitamin D status in children with epilepsy who are on AEDs.

Material and Methods: A total of 60 children diagnosed with epilepsy and receiving AEDs for at least six months were enrolled in this prospective study conducted in the Department of Pediatrics at a tertiary care hospital. Vitamin D levels were assessed before starting AEDs and after six months of therapy. Data on age, sex, type of epilepsy, duration of AED therapy, and dietary intake of vitamin D were collected.

Results: The results indicate a significant decrease in vitamin D levels after six months of AED therapy. The study highlighted the need for monitoring vitamin D status in pediatric epilepsy patients on long-term AEDs.

Conclusion: Regular monitoring and appropriate management of vitamin D levels are essential in children with epilepsy receiving antiepileptic treatment to prevent deficiencies and related complications.

Keywords: Epilepsy, Antiepileptic Drugs, Vitamin D Status, Pediatrics, Bone Health.