Assessment of Cerebral Perfusion Parameters in Post-Stroke Seizure Patients Using Magnetic Resonance Imaging

Abstract

Stroke is a significant neurological event that often leads to various complications, including post-stroke seizures (PSS), which can further exacerbate the prognosis and functional recovery. One of the mechanisms underlying post-stroke seizures is cerebral perfusion changes that occur in the affected regions. Cerebral perfusion refers to the blood flow to brain tissue, which is critical for maintaining neuronal function. This study aims to assess cerebral perfusion parameters in patients with post-stroke seizures using magnetic resonance imaging (MRI). A total of 60 patients who suffered a stroke and developed seizures were included. These patients underwent MRI with perfusion-weighted imaging (PWI) to measure cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) in both the infarcted and contralateral brain regions. The results showed that patients with post-stroke seizures exhibited significant alterations in cerebral perfusion, particularly in the areas adjacent to the infarcted tissue, with decreased CBF and increased MTT. The study found a correlation between these perfusion abnormalities and the frequency and severity of seizures, suggesting that changes in cerebral perfusion may contribute to the pathophysiology of PSS. These findings highlight the potential of MRI-based perfusion imaging as a non-invasive tool to understand the cerebral hemodynamic changes associated with post-stroke seizures and provide insight into possible therapeutic targets for managing these patients.

Keywords: post-stroke seizures, cerebral perfusion, magnetic resonance imaging, cerebral blood flow, perfusion-weighted imaging, stroke complications.