Comparative Study of Donepezil and American Ginseng on working memory of Rats

Abstract

Background: Cognitive dysfunction, particularly impairments in working memory, is a common symptom in neurodegenerative diseases such as Alzheimer's disease. Pharmacological and herbal treatments, including donepezil and American ginseng, have been proposed as potential therapies to improve memory function. This study aims to compare the effects of donepezil and American ginseng on the working memory of rats.

Objective: The study aims to assess and compare the cognitive effects of donepezil and American ginseng on the working memory of rats, using standard behavioral models.

Methods: A total of 60 male Wistar rats were divided into three groups: a control group, a donepezil group, and an American ginseng group. The animals underwent a radial arm maze task, which is a common test of working memory. Donepezil (1 mg/kg) and American ginseng (100 mg/kg) were administered orally once daily for four weeks. Cognitive performance was evaluated based on the number of correct entries and latency to the first correct entry during the task.

Results: Rats treated with donepezil and American ginseng showed significant improvements in working memory compared to the control group. However, the donepezil group demonstrated better overall performance with fewer errors and a shorter latency to the first correct entry.

Conclusion: Both donepezil and American ginseng showed potential in improving working memory in rats, with donepezil being more effective in enhancing cognitive function. This study suggests that donepezil remains a promising pharmacological agent for cognitive impairment, while American ginseng could serve as an alternative treatment for memory improvement.

Keywords: donepezil, American ginseng, working memory, rats, cognitive function, pharmacological treatment.