Study of Antinociceptive Effect of Ginger Essential Oil (GEO) in Acute Pain in Albino Mice

Abstract

Background: Ginger (Zingiber officinale) has been used for centuries in traditional medicine for its therapeutic properties, including its potential analgesic and anti-inflammatory effects. Ginger essential oil (GEO), derived from the rhizomes of the ginger plant, is believed to possess bioactive compounds that may help alleviate pain. This study aims to evaluate the antinociceptive effect of GEO in acute pain in albino mice.

Aim: To investigate the antinociceptive effect of ginger essential oil (GEO) in acute pain models in albino mice.

Methods: A total of 30 male albino mice were divided into five groups. The pain was induced using the formalin test, and GEO was administered at varying doses (50, 100, and 200 mg/kg) via oral gavage. The control group received normal saline. The nociceptive response was measured by observing the time spent in paw licking during the early and late phases of the formalin test.

Results: GEO significantly reduced paw licking time in both early and late phases of the formalin test compared to the control group. The 100 mg/kg and 200 mg/kg doses showed the most prominent reduction in pain behavior.

Conclusion: This study demonstrates that ginger essential oil possesses antinociceptive properties, suggesting its potential as a therapeutic agent for acute pain management.

Keywords: Ginger Essential Oil, Antinociceptive, Acute Pain, Albino Mice, Analgesic, Formalin Test.