Role of HPV DNA Testing versus Pap Smear in Early Detection of Cervical Cancer: A Prospective Comparative Study

Authors

  • Bishal Datta Assistant Professor, Department of Pathology, DRIEMS Institute of Health Sciences and Hospital, Odisha, India
  • Prannoy Das Assistant Professor, Department of Pathology, DRIEMS Institute of Health Sciences and Hospital, Odisha, India
  • Bhabani Charan Das Associate Professor, Department of Pathology, DRIEMS Institute of Health Sciences and Hospital, Odisha, India

DOI:

https://doi.org/10.32553/ijmbs.v10i3.3285

Keywords:

PPV

Abstract

Background: Cervical cancer remains a leading cause of cancer-related morbidity and mortality among women, especially in developing countries. Screening plays a crucial role in early detection. Conventional cytology (Pap smear) has been widely used; however, Human Papillomavirus (HPV) DNA testing has emerged as a more sensitive alternative.

Objective: To compare the diagnostic performance of HPV DNA testing and Pap smear in the early detection of cervical precancerous and cancerous lesions.

Methods: This study was carried over one year at DRIEMS Institute of Health Sciences and Hospital, Cuttack, involving 100 women aged 21–65 years. Both Pap smear and HPV DNA testing were performed. Histopathology (where indicated) was considered the gold standard. Specificity, sensitivity, negative predictive value (NPV), and positive predictive value (PPV) were calculated.

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Published

2026-06-03

How to Cite

Datta, B. ., Das, P. ., & Das, B. C. . (2026). Role of HPV DNA Testing versus Pap Smear in Early Detection of Cervical Cancer: A Prospective Comparative Study. International Journal of Medical and Biomedical Studies, 10(3), 45–50. https://doi.org/10.32553/ijmbs.v10i3.3285

Issue

Vol. 10 No. 3 (2026)

Section

Articles

License

Copyright (c) 2026 International Journal of Medical and Biomedical Studies

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This work is licensed under a Creative Commons Attribution 4.0 International License.