AN UNUSUAL PRESENTATION OF THROMBOTIC THROMBOCYTOPENIC PURPURA FOLLOWING HEPATITIS A INFECTION: A CASE REPORT

Authors

  • Mansi Kala Assistant Professor, Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
  • Siddharth Sharma Junior Resident, Department of Pathology. Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
  • Sushil Kumar Shukla Senior Resident, Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India
  • Mohd. Akram Assistant Professor, Department of Medicine, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.32553/ijmbs.v3i6.340

Keywords:

Thrombotic thrombocytopenic purpura, Hepatitis A, TTP/HUS, HAV

Abstract

Introduction: Thrombotic Thrombocytopenic Purpura (TTP) is a fulminant thromboticmicroangiopathy often manifested as clinical pentad of fever, thrombocytopenia, haemolytic anemia, renal failure and neurological abnormalities. ADAMTS13 deficiency has been noted as causative factor however secondary TTP/HUS preceded by various insult is also noted. Insults like burn, malignancy, viral infections and sepsis has been associated with TTP/HUS. Association of TTP/HUS with hepatitis A infection is rare and not reported.

Case Summary: 27 years old male was admitted with acute onset fever, drowsiness, decreased urine output and icterus. Physical examination was unremarkable except icterus. He was found to have IgM positive for hepatitis A along with evidence of microangiopathic haemolytic anemia. He was diagnosed to have Hepatitis A along with TTP/HUS and plasmapheresis was started. He improved dramatically after it. No recurrence of TTP/HUS was noted on follow up.

Conclusion: We present an interesting case of Hepatitis A as a possible trigger for Thrombotic thrombocytopenic purpura. Any haemolytic microangiopathy in hepatitis A should be carefully looked for a possibility of TTP.

Keywords: Thrombotic thrombocytopenic purpura, Hepatitis A, TTP/HUS, HAV

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Published

2019-06-25

How to Cite

Kala, M., Sharma, S., Shukla, S. K., & Akram, M. (2019). AN UNUSUAL PRESENTATION OF THROMBOTIC THROMBOCYTOPENIC PURPURA FOLLOWING HEPATITIS A INFECTION: A CASE REPORT. International Journal of Medical and Biomedical Studies, 3(6), 208–210. https://doi.org/10.32553/ijmbs.v3i6.340

Issue

Vol. 3 No. 6 (2019)

Section

Research Articles