DYSLIPIDEMIA IN HYPOTHYROIDISM PATIENTS: A HOSPITAL BASED CASE AND CONTROL STUDY.

Abstract

Objectives: This present study was to evaluate the incidence and abnormalities in lipid profile in patients with hypothyroidism.

Methods: A detail history, clinical examinations and relevant investigations were performed to all subjects. Serum free T₃ (fT₃) and T₄ (fT₄) were measured by competitive enzyme-linked immunosorbent assay (ELISA) method. Serum TSH was measured by sand-witch ELISA method. Serum cholesterol was measured by cholesterol oxidase-peroxidase (CHODPAP) method. Serum triglyceride was measured by glycerol-3-phosphate oxidase (GPO) method. Serum VLDL (in mg/dl) was calculated by dividing the value of TG by 5. Serum LDL value was calculated by Fried-Wald equation. And serum HDL level was calculated by precipitation method.

Results: Data was analysed by using software SPSS 15.0. Independent t-test was applied. Mean and standard deviations were observed. P-value was taken equal to or less than 0.05 for significant differences (p?0.05).

Conclusions: Hypothyroidism was commonly seen in elderly age group subjects. Females were more preponderance than males. Hypercholesterolemia, hyper triglyceridemia and increased LDL-cholestrol & VLDL-Cholestrol were extremely significant associated with hypothyroidism. Hence, hypothyroidism has an importantly associated with abnormal lipid profile. Therefore, biochemical screening for thyroid dysfunction should be perform in all dyslipidemic patients. Early diagnosis should be made for proper treatment of dyslipidemia in hypothyroidism patients.

Keywords: hypothyroidism, dyslipidemia, age, sex.