PREVALENCE OF DIABETES MELLITUS-ASSOCIATED GASTROINTESTINAL SYMPTOMS
Keywords:Diabetes Mellitus, Gastrointestinal, glycemic
Gastrointestinal symptoms are reportedly prevalent in diabetes, but there is a controversial causal link and sufficient population control knowledge is missing. The goal of this study was to determine whether gastrointestinal symptoms, particularly those with poor glycemic control, are more frequent in people with diabetes. A questionnaire (response rate, 60.0%) containing validated questions on the occurrence of troubling gastrointestinal symptoms over the past 3 months, diabetic status, and self-reported glycemic control was sent to fifteen thousand adults. The incidence, reported to occur regularly or very frequently, of 16 symptoms and 5 symptom complexes was compared using logistic regression analysis, age and sex adjustment. As a consequence, 8657 qualifying subjects replied overall; 423 (4.9 percent) reported diabetes. Most had type 2 diabetes mellitus (94.8 percent). Both 16 symptoms and the 5 symptom complexes, modified for age and sex, were significantly more frequent in subjects with diabetes compared to controls. Lower levels of glycemic regulation, but not the length of diabetes or the type of diabetic treatment, were significantly correlated with an increased prevalence of symptoms. To conclude, an increased incidence of upper and lower gastrointestinal symptoms is associated with diabetes mellitus. This effect can be associated with impaired glycemic control, but not with the period or form of treatment for diabetes.
Keywords: Diabetes Mellitus, Gastrointestinal, glycemic.
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