TO FIND OUT THE TOXICITY PROFILE OF TWICE WEEKLY CISPLATIN OVER CONVENTIONAL ONCE WEEKLY CISPLATIN BASED CRT IN LOCALLY ADVANCED CERVICAL CANCER.

Abstract

Background: Carcinoma cervix ranks fourth most common malignancy (for both incidence & mortality) globally and third most common diagnosed malignancy in females (~16.5%) in India, (after breast & lip/oral cavity), with about 80% of the total burden occurring in developing countries  like India.

Methods: This Prospective comparative study was conducted in the Department of Radiotherapy and Oncology TCC, IGMC, Shimla, in patients suffering from

advanced carcinoma of cervix.

Results: Hematological toxicities were seen mainly in the study group as compared to the control group (28 patients in the study group vs. 22 patients in control group). The difference was not statistically significant (p = 0.214). Grade III toxicities were seen in 5 patients in study group and 4 patients in control group. Cutaneous toxicity of different grades was seen in all the patients in the study arm and of the patients in the control arm. There was no statistically significant difference between the two arms (p=0.8121).

Conclusion: Both (Study & control) groups are comparable in terms of toxicity and are equally well tolerated by the patients.

Keywords: Chemoradiotherapy, RT, Partial response, toxicity.